QuickView for TIRAP (gene)

Gene Symbol:

TIRAP Homo sapiens

Full name:

TIR domain containing adaptor protein

Synonyms:

BACTS1, Mal, MyD88-2, wyatt, toll/interleukin-1 receptor domain-containing adapter protein, MyD88 adapter-like protein, Toll-like receptor adaptor protein, adapter protein wyatt, adaptor protein Wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein

Genomic Location:

Chr 11: 125658192-125670038

Description:

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded b...

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The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTGGA_MIR145 ,  ACACTAC_MIR1423P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-145

Cytogenetic Map:

11q24.2

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