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QuickView for TJ6M (gene)


Gene Symbol:
ATP6V0A2 Homo sapiens Homo sapiens
Full name:
ATPase H+ transporting V0 subunit a2
Synonyms:
A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS, V-type proton ATPase 116 kDa subunit a isoform 2, A2V-ATPase, ATPase, H+ transporting, lysosomal V0 subunit a2, lysosomal H(+)-transporting ATPase V0 subunit a2, regeneration and tolerance factor, v-ATPase 116 kDa, v-type proton ATPase 116 kDa subunit a, vacuolar proton translocating ATPase 116 kDa subunit a
Genomic Location:
Chr 12: 122762818-122810394
Description:
The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydroly...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12
12q24.31





GO Molecular Function

ATPase activity, coupled to transmembrane movement of substances | proton transmembrane transporter activity | enzyme binding | transmembrane transporter activity | hydrolase activity | ATPase activity | pyrophosphatase activity | catalytic activity | ATPase binding | nucleoside-triphosphatase activity | cation transmembrane transporter activity | ATPase activity, coupled | proton-exporting ATPase activity | cation-transporting ATPase activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | protein binding | proton-transporting ATPase activity, rotational mechanism | hydrolase activity, acting on acid anhydrides | ATPase coupled ion transmembrane transporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

GO Biological Process

ATP hydrolysis coupled cation transmembrane transport | cellular response to increased oxygen levels | vacuolar acidification | transferrin transport | ATPase activity, coupled to transmembrane movement of substances | establishment of localization | proton transmembrane transporter activity | regulation of autophagy | response to hormone | cellular chemical homeostasis | cellular process | proton transmembrane transport | localization | cellular homeostasis | protein transport | metal ion transport | macromolecule localization | transition metal ion transport | response to peptide hormone | regulation of cellular process | regulation of metabolic process | transmembrane transporter activity | cellular response to organonitrogen compound | pH reduction | response to stimulus | intracellular pH reduction | ATP hydrolysis coupled transmembrane transport | response to peptide | regulation of macroautophagy | metal ion homeostasis | response to nitrogen compound | cellular response to hormone stimulus | response to oxygen levels | cellular response to peptide hormone stimulus | cellular response to insulin stimulus | ATP hydrolysis coupled ion transmembrane transport | ion transmembrane transport | organic substance transport | cellular response to peptide | cation transmembrane transporter activity | insulin receptor signaling pathway | proton-exporting ATPase activity | cellular ion homeostasis | cation-transporting ATPase activity | monovalent inorganic cation transport | cellular response to oxygen levels | active transmembrane transporter activity | enzyme linked receptor protein signaling pathway | peptide transport | ion transmembrane transporter activity | ATP hydrolysis coupled proton transport | cation homeostasis | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of intracellular pH | ferric iron transport | homeostatic process | iron ion homeostasis | cation transmembrane transport | response to organic substance | regulation of pH | proton-transporting ATPase activity, rotational mechanism | response to insulin | cell surface receptor signaling pathway | amide transport | chemical homeostasis | immune response | energy coupled proton transmembrane transport, against electrochemical gradient | ion homeostasis | inorganic cation transmembrane transport | cellular iron ion homeostasis | establishment of protein localization | regulation of cellular pH | ATPase coupled ion transmembrane transporter activity | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | cellular monovalent inorganic cation homeostasis | monovalent inorganic cation transmembrane transporter activity | protein localization | cation transport | iron ion transport | response to organonitrogen compound | cellular metal ion homeostasis | transmembrane receptor protein tyrosine kinase signaling pathway | ion transport | transition metal ion homeostasis | immune system process | cellular response to organic substance | signal transduction

GO Cellular Component

secretory granule | proton-transporting V-type ATPase, V0 domain | integral component of membrane | intracellular membrane-bounded organelle | endocytic vesicle membrane | organelle membrane | cytoplasmic vesicle | proton-transporting V-type ATPase complex | cell | intrinsic component of membrane | cytoplasm | acrosomal vesicle | intracellular organelle | vacuolar proton-transporting V-type ATPase complex | endosome membrane | vacuolar proton-transporting V-type ATPase, V0 domain | protein-containing complex | secretory vesicle | phagocytic vesicle membrane | endomembrane system | plasma membrane | vacuole | vesicle | lytic vacuole | endosome | membrane-bounded organelle | organelle | vesicle membrane | lysosome | cell periphery | proton-transporting two-sector ATPase complex | intracellular vesicle | endocytic vesicle | intracellular | lysosomal membrane | membrane | cytoplasmic vesicle membrane | proton-transporting two-sector ATPase complex, proton-transporting domain | phagocytic vesicle | vacuolar membrane