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QuickView for TK25 (gene)


Gene Symbol:
FGFR2 Homo sapiens Homo sapiens
Full name:
fibroblast growth factor receptor 2
Synonyms:
BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2, BEK fibroblast growth factor receptor, bacteria-expressed kinase, keratinocyte growth factor receptor, protein tyrosine kinase, receptor like 14
Genomic Location:
Chr 10: 123227845-123347962
Description:
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 10
10q26.13





GO Molecular Function

guanyl-nucleotide exchange factor activity | transmembrane receptor protein tyrosine kinase activity | GTPase binding | fibroblast growth factor-activated receptor activity | transmembrane signaling receptor activity | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | Ras GTPase binding | growth factor binding | molecular function regulator | catalytic activity | fibroblast growth factor binding | ATP binding | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | phosphatidylinositol 3-kinase activity | identical protein binding | ion binding | organic cyclic compound binding | heparin binding | purine ribonucleoside triphosphate binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein tyrosine kinase activity | protein binding | protein homodimerization activity | 1-phosphatidylinositol-3-kinase activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | glycosaminoglycan binding | transferase activity | small GTPase binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of smooth muscle cell proliferation | regulation of ERK1 and ERK2 cascade | brain development | limb development | molting cycle | branch elongation involved in salivary gland morphogenesis | cell morphogenesis | inner ear morphogenesis | ventricular cardiac muscle tissue morphogenesis | positive regulation of macromolecule biosynthetic process | fibroblast growth factor receptor signaling pathway involved in hemopoiesis | branching morphogenesis of a nerve | guanyl-nucleotide exchange factor activity | epidermis morphogenesis | neuron projection morphogenesis | response to lipopolysaccharide | cranial skeletal system development | developmental process involved in reproduction | muscle tissue development | intracellular signal transduction | mammary gland duct morphogenesis | prostate gland growth | otic vesicle development | morphogenesis of an epithelium | positive regulation of striated muscle tissue development | regulation of programmed cell death | fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | phosphatidylinositol metabolic process | branching involved in salivary gland morphogenesis | regulation of osteoblast proliferation | mammary gland bud morphogenesis | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | bone development | regulation of heart growth | otic vesicle formation | cell differentiation | positive regulation of epithelial cell proliferation | bone mineralization | respiratory tube development | nervous system development | epithelial to mesenchymal transition | response to drug | multicellular organism growth | organ growth | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | generation of neurons | phosphatidylinositol-3-phosphate biosynthetic process | response to antibiotic | mesenchyme development | salivary gland morphogenesis | phospholipid metabolic process | blood vessel morphogenesis | regulation of cardiac muscle cell proliferation | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | regulation of branching involved in prostate gland morphogenesis | regulation of epithelial cell proliferation involved in lung morphogenesis | cell projection morphogenesis | epithelial tube morphogenesis | limb morphogenesis | mesoderm morphogenesis | odontogenesis | heart morphogenesis | negative regulation of signaling | developmental growth | neuron development | central nervous system neuron differentiation | reproductive system development | mesoderm development | fibroblast growth factor-activated receptor activity | mammary gland bud formation | immune system development | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | glandular epithelial cell differentiation | negative regulation of apoptotic process | digestive tract morphogenesis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | forebrain neuron differentiation | positive regulation of cell division | regulation of canonical Wnt signaling pathway | regulation of smoothened signaling pathway | negative regulation of cellular metabolic process | mammary gland specification | tissue development | regulation of cell differentiation | muscle structure development | ventricular septum morphogenesis | cellular response to retinoic acid | regulation of protein kinase B signaling | regulation of cellular process | regulation of osteoblast differentiation | regulation of apoptotic process | cellular response to lipid | labyrinthine layer morphogenesis | regulation of metabolic process | forebrain ventricular zone progenitor cell division | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | cellular lipid metabolic process | prostate gland epithelium morphogenesis | epithelial tube branching involved in lung morphogenesis | MAPK cascade | response to transforming growth factor beta | regulation of cell division | urogenital system development | mammary gland morphogenesis | head development | muscle organ morphogenesis | response to stimulus | lacrimal gland development | vasculature development | cell morphogenesis involved in neuron differentiation | lung lobe morphogenesis | respiratory system development | cellular response to fibroblast growth factor stimulus | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | mesoderm formation | gland morphogenesis | response to stress | regulation of cell proliferation | tube morphogenesis | branching involved in labyrinthine layer morphogenesis | cardiac muscle tissue development | muscle tissue morphogenesis | programmed cell death | epithelial tube formation | reproduction | embryonic skeletal system development | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development | response to alcohol | cardiovascular system development | embryonic digestive tract morphogenesis | cardiac ventricle morphogenesis | midbrain development | response to molecule of bacterial origin | positive regulation of lipase activity | axis elongation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | cellular biosynthetic process | kidney development | embryo development | regulation of morphogenesis of a branching structure | macromolecule modification | cell-cell signaling | mammary gland formation | molecular function regulator | pyramidal neuron development | embryonic placenta development | blood vessel development | response to ethanol | regulation of nucleic acid-templated transcription | somatic stem cell division | central nervous system neuron development | lung alveolus development | apoptotic process | response to external biotic stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | ureteric bud development | multicellular organism development | regulation of MAPK cascade | neuroblast proliferation | phosphorus metabolic process | mammary gland development | epithelial cell differentiation involved in prostate gland development | positive regulation of muscle organ development | positive regulation of protein kinase B signaling | regulation of catalytic activity | lipid metabolic process | forebrain neuron development | regulation of phosphorylation | fibroblast growth factor receptor signaling pathway | regulation of ossification | hair follicle morphogenesis | embryonic digestive tract development | wound healing | positive regulation of cell cycle | regulation of gene expression | lateral sprouting from an epithelium | stem cell proliferation | ventricular zone neuroblast division | kidney epithelium development | axon development | outflow tract morphogenesis | response to lipid | branching involved in prostate gland morphogenesis | stem cell division | organophosphate metabolic process | regulation of fibroblast growth factor receptor signaling pathway | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of smooth muscle cell differentiation | animal organ morphogenesis | phospholipid biosynthetic process | specification of animal organ identity | limb bud formation | protein autophosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | bone growth | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | phosphatidylinositol 3-kinase activity | morphogenesis of an epithelial fold | axonogenesis | positive regulation of cell proliferation in bone marrow | positive regulation of hydrolase activity | stem cell differentiation | cell proliferation | biosynthetic process | positive regulation of cardiac muscle cell proliferation | labyrinthine layer development | cell division | neuronal stem cell division | regulation of cellular protein metabolic process | angiogenesis | phosphorylation | mesonephric epithelium development | cardiac septum morphogenesis | mesenchymal cell differentiation involved in lung development | digestive tract development | lipid biosynthetic process | regulation of phospholipase activity | epidermis development | response to toxic substance | skin development | protein phosphorylation | cell morphogenesis involved in differentiation | bud elongation involved in lung branching | mesonephros development | post-embryonic development | phosphate-containing compound metabolic process | sensory organ development | lipid phosphorylation | response to bacterium | chordate embryonic development | animal organ formation | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | skeletal system morphogenesis | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | pyramidal neuron differentiation | heart development | lipid modification | limbic system development | positive regulation of cell proliferation | regulation of protein phosphorylation | bone morphogenesis | embryo development ending in birth or egg hatching | glycerolipid metabolic process | regulation of RNA metabolic process | renal system development | response to retinoic acid | negative regulation of apoptotic process in bone marrow | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | cell proliferation in forebrain | protein tyrosine kinase activity | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | neuron differentiation | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | positive regulation of organ growth | ventricular septum development | negative regulation of epithelial cell proliferation | protein metabolic process | regionalization | cardiac ventricle development | positive regulation of protein modification process | regulation of growth | hair cycle | response to organic substance | gland development | regulation of cardiac muscle tissue development | tissue morphogenesis | digestive system development | glycerophospholipid biosynthetic process | 1-phosphatidylinositol-3-kinase activity | branching morphogenesis of an epithelial tube | epithelial cell proliferation | response to wounding | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | ventricular cardiac muscle tissue development | anatomical structure development | developmental growth involved in morphogenesis | branch elongation of an epithelium | cell surface receptor signaling pathway | embryonic skeletal system morphogenesis | cell projection organization | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of RNA biosynthetic process | prostate epithelial cord elongation | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | ear development | hair cycle process | Ras guanyl-nucleotide exchange factor activity | forebrain generation of neurons | morphogenesis of embryonic epithelium | protein kinase activity | neuron projection development | mesenchymal cell proliferation | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | lung-associated mesenchyme development | forebrain development | positive regulation of ERK1 and ERK2 cascade | skin epidermis development | regulation of Wnt signaling pathway | neural precursor cell proliferation | regulation of phosphate metabolic process | biomineral tissue development | mammary gland epithelium development | phosphatidylinositol biosynthetic process | prostate gland morphogenesis | positive regulation of muscle tissue development | positive regulation of phospholipase activity | orbitofrontal cortex development | positive regulation of MAPK cascade | lung development | morphogenesis of a branching epithelium | fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow | positive regulation of canonical Wnt signaling pathway | anatomical structure formation involved in morphogenesis | neuroblast division | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | regulation of cell communication | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of transcription, DNA-templated | cell development | regulation of developmental growth | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | phosphatidylinositol phosphorylation | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | regulation of organ growth | response to biotic stimulus | reproductive structure development | regulation of developmental process | forebrain neuroblast division | glycerophospholipid metabolic process | epithelial cell proliferation involved in salivary gland morphogenesis | kinase activity | regulation of mesenchymal cell proliferation | developmental process | regulation of muscle cell differentiation | cardiac septum development | cellular protein modification process | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | membranous septum morphogenesis | negative regulation of cell proliferation | mesenchymal cell proliferation involved in lung development | response to fibroblast growth factor | positive regulation of mesenchymal cell proliferation | positive regulation of nucleic acid-templated transcription | positive regulation of heart growth | lung morphogenesis | epithelial cell differentiation | embryonic placenta morphogenesis | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | cardiac chamber development | tube formation | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow | regulation of cell fate commitment | central nervous system development | mesodermal cell differentiation | transmembrane receptor protein tyrosine kinase signaling pathway | in utero embryonic development | positive regulation of metabolic process | ossification | skeletal system development | gastrulation | immune system process | positive regulation of Wnt signaling pathway | lung lobe development | cellular metabolic process | hematopoietic or lymphoid organ development | placenta development | cellular response to organic substance | exocrine system development | regulation of cell death | positive regulation of cardiac muscle tissue development | regulation of smooth muscle cell proliferation | salivary gland development | negative regulation of cell death | circulatory system development | endochondral bone growth | ear morphogenesis | fibroblast growth factor receptor signaling pathway involved in mammary gland specification | muscle organ development | otic vesicle morphogenesis | response to other organism | positive regulation of signaling | hair follicle development | positive regulation of epithelial cell proliferation involved in lung morphogenesis | signal transduction | regulation of signaling | mesonephric tubule development | positive regulation of gene expression | embryonic pattern specification | outflow tract septum morphogenesis | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | synapse | extracellular matrix | cytoplasmic vesicle | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | Golgi apparatus | protein-containing complex | endomembrane system | nucleoplasm | plasma membrane | vesicle | cytoplasmic region | integral component of plasma membrane | extracellular region | cell cortex | membrane-bounded organelle | nucleus | organelle | cell periphery | excitatory synapse | membrane-enclosed lumen | intracellular vesicle | cell surface | intracellular | membrane | intrinsic component of plasma membrane