QuickView for TLR3 (gene)
- Gene Symbol:
- TLR3
Homo sapiens - Full name:
- toll like receptor 3
- Synonyms:
- CD283, IIAE2, toll-like receptor 3
- Genomic Location:
- Chr 4: 187227303-187243246
- Description:
-
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are exp...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
4q35.1
GO Molecular Function
transmembrane signaling receptor activity | nucleic acid binding | signaling receptor activity | identical protein binding | organic cyclic compound binding | protein binding | heterocyclic compound binding | RNA binding | double-stranded RNA binding
GO Biological Process
positive regulation of immune response | positive regulation of macromolecule biosynthetic process | response to virus | negative regulation of immune system process | hyperosmotic response | response to cytokine | immune response-regulating signaling pathway | developmental process involved in reproduction | intracellular signal transduction | positive regulation of apoptotic process | negative regulation of MyD88-independent toll-like receptor signaling pathway | positive regulation of DNA-binding transcription factor activity | gonad development | regulation of programmed cell death | defense response to other organism | necroptotic process | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | regulation of interferon-beta biosynthetic process | defense response | response to drug | negative regulation of osteoclast differentiation | positive regulation of phosphate metabolic process | necroptotic signaling pathway | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | toll-like receptor signaling pathway | response to exogenous dsRNA | regulation of cytokine biosynthetic process | extrinsic apoptotic signaling pathway | negative regulation of signaling | reproductive system development | I-kappaB phosphorylation | programmed necrotic cell death | regulation of MyD88-independent toll-like receptor signaling pathway | positive regulation of protein kinase activity | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | positive regulation of interferon-gamma biosynthetic process | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of interferon-beta production | regulation of angiogenesis | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | positive regulation of interferon-gamma production | positive regulation of cellular protein metabolic process | negative regulation of toll-like receptor signaling pathway | cellular response to interferon-gamma | positive regulation of tumor necrosis factor production | development of primary sexual characteristics | regulation of type I interferon production | regulation of type III interferon production | positive regulation of stress-activated protein kinase signaling cascade | regulation of vasculature development | response to stimulus | positive regulation of NIK/NF-kappaB signaling | cellular response to mechanical stimulus | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | positive regulation of chemokine biosynthetic process | response to interferon-beta | programmed cell death | positive regulation of cytokine biosynthetic process | activation of innate immune response | reproduction | immune response-activating signal transduction | cellular response to organic cyclic compound | positive regulation of RNA biosynthetic process | negative regulation of hemopoiesis | protein modification process | macromolecule modification | activation of protein kinase activity | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | response to external biotic stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | pattern recognition receptor signaling pathway | multicellular organism development | regulation of toll-like receptor signaling pathway | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | response to dsRNA | regulation of catalytic activity | regulation of phosphorylation | regulation of gene expression | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | cellular response to exogenous dsRNA | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | positive regulation of interleukin-12 production | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | cellular response to cytokine stimulus | response to osmotic stress | regulation of cellular protein metabolic process | TRIF-dependent toll-like receptor signaling pathway | phosphorylation | positive regulation of chemokine production | microglial cell activation | activation of NF-kappaB-inducing kinase activity | protein phosphorylation | regulation of tumor necrosis factor production | phosphate-containing compound metabolic process | cellular response to drug | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of interferon-beta biosynthetic process | inflammatory response | regulation of cytokine production involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | cellular response to dsRNA | defense response to bacterium | regulation of protein phosphorylation | positive regulation of type III interferon production | regulation of RNA metabolic process | apoptotic signaling pathway | detection of virus | positive regulation of interferon-alpha production | positive regulation of molecular function | development of primary male sexual characteristics | activation of immune response | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of hemopoiesis | MyD88-independent toll-like receptor signaling pathway | regulation of kinase activity | male sex differentiation | response to mechanical stimulus | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | male gonad development | positive regulation of cell death | positive regulation of interleukin-6 production | macrophage activation | immune response | organic substance metabolic process | cell death | animal organ development | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of dendritic cell cytokine production | response to interferon-gamma | positive regulation of cytokine production | regulation of JNK cascade | cell activation | positive regulation of MAPK cascade | toll-like receptor 3 signaling pathway | regulation of osteoclast differentiation | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | I-kappaB kinase/NF-kappaB signaling | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | cellular response to interferon-beta | response to biotic stimulus | reproductive structure development | regulation of developmental process | developmental process | cellular protein modification process | regulation of chemokine production | positive regulation of transcription, DNA-templated | necrotic cell death | innate immune response | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | NIK/NF-kappaB signaling | positive regulation of interferon-alpha biosynthetic process | positive regulation of metabolic process | regulation of interferon-gamma production | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | sex differentiation | positive regulation of type I interferon production | regulation of interleukin-6 production | regulation of inflammatory response | positive regulation of angiogenesis | negative regulation of myeloid leukocyte differentiation | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of cell differentiation | positive regulation of toll-like receptor signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | positive regulation of interferon-beta production | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | endolysosome | intracellular membrane-bounded organelle | extracellular matrix | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | plasma membrane | vacuole | vesicle | lytic vacuole | integral component of plasma membrane | Golgi membrane | endosome | extracellular region | membrane-bounded organelle | organelle | lysosome | extracellular space | cell periphery | early endosome | endolysosome membrane | intracellular vesicle | cell surface | intracellular | lysosomal membrane | membrane | intrinsic component of plasma membrane | vacuolar membrane
