QuickView for TMX (gene)

Gene Symbol:

TMX1 Homo sapiens

Full name:

thioredoxin related transmembrane protein 1

Synonyms:

PDIA11, TMX, TXNDC, TXNDC1, thioredoxin-related transmembrane protein 1, protein disulfide isomerase family A, member 11, thioredoxin domain containing 1, thioredoxin domain-containing protein 1, transmembrane Trx-related protein

Genomic Location:

Chr 14: 50776636-50794123

Description:

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family,...

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This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  GABP_B ,  TGTGTGA_MIR377 ,  TGCGCANK_UNKNOWN ,  GTGCCAA_MIR96 ,  MGGAAGTG_GABP_B ,  TAATAAT_MIR126 ,  SCGGAAGY_ELK1_02 ,  AAGCACA_MIR218

Cytogenetic Map:

14q22.1

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