QuickView for TNFRSF10A (gene)
- Gene Symbol:
- TNFRSF10A
Homo sapiens - Full name:
- TNF receptor superfamily member 10a
- Synonyms:
- APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10A, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, cytotoxic TRAIL receptor, death receptor 4, tumor necrosis factor receptor superfamily member 10a variant 2, tumor necrosis factor receptor superfamily, member 10a
- Genomic Location:
- Chr 8: 23104915-23138584
- Description:
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is req...
- External Links:
- Entrez Gene
- Cytogenetic Map:
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8p21.3
GO Molecular Function
TRAIL binding | transmembrane signaling receptor activity | enzyme binding | death receptor activity | signaling receptor activity | protein binding | transcription factor binding | protease binding
GO Biological Process
regulation of cysteine-type endopeptidase activity | response to cytokine | cell motility | intracellular signal transduction | positive regulation of apoptotic process | regulation of programmed cell death | negative regulation of cellular process | cellular response to tumor necrosis factor | positive regulation of phosphate metabolic process | cellular process | localization | extrinsic apoptotic signaling pathway | TRAIL-activated apoptotic signaling pathway | negative regulation of signaling | positive regulation of protein kinase activity | negative regulation of apoptotic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | response to stimulus | positive regulation of NIK/NF-kappaB signaling | cellular response to mechanical stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | positive regulation of cysteine-type endopeptidase activity | programmed cell death | positive regulation of proteolysis | extrinsic apoptotic signaling pathway via death domain receptors | activation of protein kinase activity | leukocyte migration | locomotion | apoptotic process | regulation of signal transduction | cell migration | regulation of peptidase activity | regulation of catalytic activity | regulation of phosphorylation | regulation of extrinsic apoptotic signaling pathway | death receptor activity | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of hydrolase activity | negative regulation of extrinsic apoptotic signaling pathway | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | regulation of apoptotic signaling pathway | activation of NF-kappaB-inducing kinase activity | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | apoptotic signaling pathway | positive regulation of molecular function | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | response to mechanical stimulus | regulation of intracellular signal transduction | cell surface receptor signaling pathway | activation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of programmed cell death | positive regulation of cell death | cell death | positive regulation of programmed cell death | positive regulation of kinase activity | tumor necrosis factor-mediated signaling pathway | regulation of phosphate metabolic process | regulation of cell communication | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | positive regulation of phosphorylation | regulation of endopeptidase activity | NIK/NF-kappaB signaling | positive regulation of metabolic process | immune system process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | regulation of phosphorus metabolic process
GO Cellular Component
cell | plasma membrane | cell periphery | cell surface | intracellular | membrane
