QuickView for TNFSF4 (gene)

Gene Symbol:

TNFSF4 Homo sapiens

Full name:

TNF superfamily member 4

Synonyms:

CD134L, CD252, GP34, OX-40L, OX4OL, TNLG2B, TXGP1, tumor necrosis factor ligand superfamily member 4, CD134 ligand, OX40 antigen ligand, glycoprotein Gp34, tax-transcriptionally activated glycoprotein 1 (34kD), tumor necrosis factor (ligand) superfamily member 4, tumor necrosis factor ligand 2B, tumor necrosis factor superfamily member 4

Genomic Location:

Chr 1: 171419493-171443094

Description:

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splic...

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This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  P53_DECAMER_Q2 ,  FOXO4_01 ,  EVI1_04 ,  AML1_01 ,  AP4_Q6 ,  RRAGTTGT_UNKNOWN ,  HMGIY_Q6 ,  AML1_Q6 ,  TTGTTT_FOXO4_01 ,  CAGCTG_AP4_Q5 ,  CRX_Q4 ,  COREBINDINGFACTOR_Q6 ,  NFKB_Q6 ,  CTGRYYYNATT_UNKNOWN ,  FOXO4_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-188

Cytogenetic Map:

1q25.1

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