QuickView for TNNC1 (gene)

Gene Symbol:

TNNC1 Homo sapiens

Full name:

troponin C1, slow skeletal and cardiac type

Synonyms:

CMD1Z, CMH13, TN-C, TNC, TNNC, troponin C, slow skeletal and cardiac muscles, cardiac troponin C, slow twitch skeletal/cardiac muscle troponin C, troponin C type 1 (slow)

Genomic Location:

Chr 3: 52460158-52463098

Description:

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC ab...

View Full Description

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SRF_01 ,  RSRFC4_01 ,  HOXA4_Q2 ,  YTATTTTNR_MEF2_02 ,  SRF_Q6 ,  RSRFC4_Q2 ,  HP1SITEFACTOR_Q6 ,  AMEF2_Q6 ,  GATA1_04 ,  TAAWWATAG_RSRFC4_Q2 ,  MEF2_02 ,  MEF2_01 ,  PITX2_Q2 ,  SRF_Q4 ,  HMEF2_Q6 ,  GR_01 ,  CP2_02 ,  TGACAGNY_MEIS1_01 ,  WCAANNNYCAG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  CACBINDINGPROTEIN_Q6 ,  AACTTT_UNKNOWN ,  TCF1P_Q6 ,  CCAWWNAAGG_SRF_Q4 ,  HNF4_01_B ,  SRF_C ,  GGGTGGRR_PAX4_03 ,  MEF2_Q6_01

View More

View Less

Cytogenetic Map:

3p21.1

search → result