QuickView for TNPO3 (gene)

Gene Symbol:

TNPO3 Homo sapiens

Full name:

transportin 3

Synonyms:

IPO12, LGMD1F, MTR10A, TRN-SR, TRN-SR2, TRNSR, transportin-3, imp12, importin 12, limb girdle muscular dystrophy 1F (autosomal dominant), transportin-SR

Genomic Location:

Chr 7: 128382184-128482434

Description:

The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a n...

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The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  GATA1_01 ,  ACACTCC_MIR122A ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  RGAANNTTC_HSF1_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  HSF1_01 ,  LMO2COM_02 ,  E2F1_Q3_01 ,  MGGAAGTG_GABP_B ,  ACTGAAA_MIR30A3P_MIR30E3P ,  TGCCAAR_NF1_Q6 ,  HSF_Q6 ,  SOX5_01 ,  AHRARNT_01 ,  NCX_01 ,  TTGTTT_FOXO4_01 ,  CHOP_01 ,  SCGGAAGY_ELK1_02 ,  STAT1_01 ,  GCTNWTTGK_UNKNOWN ,  PAX4_03 ,  RRCCGTTA_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-30-3p

Cytogenetic Map:

7q32.1

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