QuickView for TOBL (gene)
- Gene Symbol:
- TOB2
Homo sapiens - Full name:
- transducer of ERBB2, 2
- Synonyms:
- APRO5, TOB4, TOBL, TROB2, protein Tob2, protein Tob4, transducer of erbB-2 2
- Genomic Location:
- Chr 22: 40159438-40172973
- Description:
-
TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for let-7 , Predicted Gene Targets for miR-130 , Predicted Gene Targets for miR-23 , Predicted Gene Targets for miR-24 , Predicted Gene Targets for miR-25 , Predicted Gene Targets for miR-324-3p , Predicted Gene Targets for miR-329 , Predicted Gene Targets for miR-34 , Predicted Gene Targets for miR-93 , Predicted Gene Targets for miR-124a
- Cytogenetic Map:
-
22q13.2
GO Molecular Function
hormone receptor binding | signaling receptor binding | transcription corepressor activity | nuclear hormone receptor binding | protein binding | transcription factor binding | transcription coregulator activity | vitamin D receptor binding
GO Biological Process
negative regulation of immune system process | regulation of immune system process | negative regulation of cellular process | negative regulation of RNA biosynthetic process | negative regulation of osteoclast differentiation | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of myeloid cell differentiation | negative regulation of cellular metabolic process | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | gamete generation | regulation of cellular process | regulation of metabolic process | female gamete generation | regulation of cell proliferation | reproduction | negative regulation of metabolic process | negative regulation of hemopoiesis | regulation of nucleic acid-templated transcription | reproductive process | regulation of ossification | regulation of gene expression | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | transcription corepressor activity | positive regulation of ossification | regulation of cellular metabolic process | regulation of RNA metabolic process | multicellular organism reproduction | regulation of hemopoiesis | regulation of RNA biosynthetic process | negative regulation of biosynthetic process | regulation of osteoclast differentiation | regulation of developmental process | negative regulation of cell proliferation | transcription coregulator activity | sexual reproduction | negative regulation of myeloid leukocyte differentiation | negative regulation of cell differentiation | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular
