QuickView for TOGp (gene)

Gene Symbol:

CKAP5 Homo sapiens

Full name:

cytoskeleton associated protein 5

Synonyms:

CHTOG, MSPS, TOG, TOGp, ch-TOG, cytoskeleton-associated protein 5, colonic and hepatic tumor over-expressed gene protein, colonic and hepatic tumor overexpressed gene protein

Genomic Location:

Chr 11: 46721660-46824419

Description:

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymer...

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This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAGCTTT_MIR9 ,  TGTATGA_MIR4853P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-485-3p

Cytogenetic Map:

11p11.2

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