QuickView for TOM1L2 (gene)

Gene Symbol:

TOM1L2 Homo sapiens

Full name:

target of myb1 like 2 membrane trafficking protein

Synonyms:

TOM1-like protein 2, target of Myb-like protein 2, target of myb1-like 2

Genomic Location:

Chr 17: 17687547-17816509

Description:

This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thoug...

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This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

USF_Q6 ,  CACGTG_MYC_Q2 ,  CYTAGCAAY_UNKNOWN ,  HNF4_DR1_Q3 ,  AR_Q6 ,  DR1_Q3 ,  GTCAGGA_MIR378 ,  TGCCAAR_NF1_Q6 ,  SPZ1_01 ,  HFH4_01 ,  USF_01 ,  TTGTTT_FOXO4_01 ,  COUP_DR1_Q6 ,  AACTTT_UNKNOWN ,  PPAR_DR1_Q2 ,  USF_02 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-378

Cytogenetic Map:

17p11.2

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