QuickView for TP73 (gene)
- Gene Symbol:
- TP73
Homo sapiens - Full name:
- tumor protein p73
- Synonyms:
- P73, tumor protein p73, p53-like transcription factor, p53-related protein
- Genomic Location:
- Chr 1: 3558989-3639716
- Description:
-
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (li...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
1p36.32
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | p53 binding | DNA binding | MDM2/MDM4 family protein binding | sequence-specific double-stranded DNA binding | identical protein binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of neurogenesis | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | establishment of localization | regulation of immune system process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | regulation of MAP kinase activity | regulation of heart growth | regulation of protein localization to membrane | cell differentiation | negative regulation of organ growth | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | response to drug | regulation of hematopoietic progenitor cell differentiation | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | generation of neurons | membrane organization | regulation of cardiac muscle cell proliferation | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | localization | negative regulation of developmental growth | regulation of striated muscle tissue development | positive regulation of protein kinase activity | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | interspecies interaction between organisms | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | urogenital system development | negative regulation of cardiac muscle tissue development | response to stimulus | regulation of cellular protein localization | positive regulation of protein metabolic process | response to stress | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | programmed cell death | cellular nitrogen compound metabolic process | positive regulation of gliogenesis | negative regulation of muscle tissue development | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | cellular biosynthetic process | kidney development | mitochondrion organization | regulation of oligodendrocyte differentiation | activation of protein kinase activity | positive regulation of mitochondrion organization | DNA repair | regulation of nucleic acid-templated transcription | response to nitrogen compound | apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | multicellular organism development | regulation of MAPK cascade | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | cellular response to DNA damage stimulus | protein complex oligomerization | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | positive regulation of cell cycle | regulation of hematopoietic stem cell differentiation | regulation of neuron differentiation | regulation of gene expression | regulation of mitochondrial membrane permeability | cellular response to stress | cell cycle | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | mitochondrial transport | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | protein tetramerization | mismatch repair | regulation of apoptotic signaling pathway | regulation of mitochondrion organization | mitochondrial membrane organization | negative regulation of cardiac muscle cell proliferation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of striated muscle tissue development | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of stem cell differentiation | renal system development | positive regulation of transport | viral process | apoptotic signaling pathway | regulation of mitotic cell cycle | positive regulation of molecular function | positive regulation of cell cycle arrest | activation of MAPK activity | protein-containing complex assembly | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of cardiac muscle tissue development | regulation of hemopoiesis | cell cycle arrest | regulation of kinase activity | DNA metabolic process | regulation of intracellular signal transduction | anatomical structure development | positive regulation of neurogenesis | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | metabolic process | positive regulation of cell development | regulation of RNA biosynthetic process | positive regulation of glial cell differentiation | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | animal organ development | negative regulation of neuron differentiation | gene expression | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | intrinsic apoptotic signaling pathway by p53 class mediator | transcription, DNA-templated | positive regulation of MAPK cascade | negative regulation of cell cycle | regulation of glial cell differentiation | regulation of cell communication | regulation of membrane permeability | regulation of gliogenesis | signaling | regulation of transcription, DNA-templated | regulation of developmental growth | positive regulation of phosphorylation | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | regulation of organ growth | regulation of nervous system development | regulation of developmental process | developmental process | organelle organization | positive regulation of cell cycle process | positive regulation of oligodendrocyte differentiation | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | regulation of protein localization | regulation of cell death | signal transduction by p53 class mediator | negative regulation of cell development | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | Golgi apparatus | endomembrane system | nucleoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular | cell junction
