QuickView for TPEF (gene)

Gene Symbol:

TMEFF2 Homo sapiens

Full name:

transmembrane protein with EGF like and two follistatin like domains 2

Synonyms:

CT120.2, HPP1, TENB2, TPEF, TR, TR-2, tomoregulin-2, cancer/testis antigen family 120, member 2, hyperplastic polyposis protein 1, transmembrane protein TENB2, transmembrane protein with EGF-like and two follistatin-like domains

Genomic Location:

Chr 2: 192522988-192767889

Description:

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice va...

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This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  AP3_Q6 ,  CAGGTG_E12_Q6 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GTTATAT_MIR410 ,  RORA2_01 ,  AACTTT_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

2q32.3

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