QuickView for TPK1 (gene)
- Gene Symbol:
- TPK1
Homo sapiens - Full name:
- thiamin pyrophosphokinase 1
- Synonyms:
- HTPK1, PP20, THMD5, thiamin pyrophosphokinase 1, placental protein 20, thiamine diphosphokinase, thiamine kinase
- Genomic Location:
- Chr 7: 143779967-144164079
- Description:
-
The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Gallus gallus , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
7q35
GO Molecular Function
ribonucleotide binding | vitamin binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | thiamine diphosphokinase activity | purine ribonucleoside triphosphate binding | transferase activity, transferring phosphorus-containing groups | transferase activity | thiamine binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
sulfur compound metabolic process | thiamine-containing compound metabolic process | cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | thiamine diphosphate metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cofactor metabolic process | cellular biosynthetic process | nitrogen compound metabolic process | coenzyme biosynthetic process | phosphorus metabolic process | organophosphate metabolic process | cofactor biosynthetic process | small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | phosphorylation | phosphate-containing compound metabolic process | drug metabolic process | thiamine metabolic process | vitamin metabolic process | metabolic process | thiamine diphosphate biosynthetic process | organic substance metabolic process | kinase activity | heterocycle metabolic process | cellular metabolic process
GO Cellular Component
cell | cytoplasm | cytosol | intracellular
