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QuickView for TPKC1 (gene)


Gene Symbol:
KCNK2 Homo sapiens Homo sapiens
Full name:
potassium two pore domain channel subfamily K member 2
Synonyms:
K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e, potassium channel subfamily K member 2, K2P2.1 potassium channel, TREK-1 K(+) channel subunit, TWIK-related potassium channel 1, outward rectifying potassium channel protein TREK-1, potassium channel subfamily k member 2 variant 1, potassium channel subfamily k member 2 variant 2, potassium channel, two pore domain subfamily K, member 2, potassium inwardly-rectifying channel, subfamily K, member 2, tandem-pore-domain potassium channel TREK-1, two pore domain potassium channel TREK-1, two pore potassium channel TPKC1, two-pore potassium channel 1
Genomic Location:
Chr 1: 213245508-213477059
Description:
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intrace...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Pan troglodytes Canis lupus familiaris Danio rerio Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1
1q41





GO Molecular Function

voltage-gated ion channel activity | passive transmembrane transporter activity | potassium ion leak channel activity | transmembrane transporter activity | ion gated channel activity | leak channel activity | cation transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | voltage-gated potassium channel activity | potassium channel activity | metal ion transmembrane transporter activity | voltage-gated cation channel activity | potassium ion transmembrane transporter activity | outward rectifier potassium channel activity | cation channel activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

cellular response to decreased oxygen levels | establishment of localization | negative regulation of cellular process | regulation of heart growth | negative regulation of organ growth | voltage-gated ion channel activity | negative regulation of DNA metabolic process | regulation of cardiac muscle cell proliferation | cellular process | negative regulation of DNA biosynthetic process | negative regulation of muscle organ development | localization | passive transmembrane transporter activity | metal ion transport | positive regulation of cellular response to hypoxia | negative regulation of developmental growth | regulation of striated muscle tissue development | response to hypoxia | negative regulation of cellular metabolic process | potassium ion leak channel activity | regulation of cellular process | regulation of metabolic process | transmembrane transporter activity | negative regulation of cardiac muscle tissue development | response to stimulus | ion gated channel activity | cellular response to hypoxia | response to stress | regulation of cell proliferation | negative regulation of muscle tissue development | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of cellular response to stress | system development | response to oxygen levels | negative regulation of growth | regulation of cellular response to hypoxia | multicellular organism development | learning or memory | ion transmembrane transport | leak channel activity | cellular response to stress | nervous system process | cation transmembrane transporter activity | response to axon injury | monovalent inorganic cation transport | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | cognition | sensory organ development | negative regulation of cardiac muscle cell proliferation | cell communication | regulation of cellular metabolic process | voltage-gated potassium channel activity | inner ear development | negative regulation of striated muscle tissue development | heart development | cation transmembrane transport | potassium channel activity | cardiac ventricle development | regulation of growth | regulation of cardiac muscle tissue development | response to wounding | response to mechanical stimulus | metal ion transmembrane transporter activity | anatomical structure development | voltage-gated cation channel activity | potassium ion transmembrane transporter activity | ear development | behavior | positive regulation of cell death | negative regulation of biosynthetic process | animal organ development | inorganic cation transmembrane transport | outward rectifier potassium channel activity | cation channel activity | memory | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | regulation of developmental growth | voltage-gated channel activity | cation transport | channel activity | regulation of organ growth | regulation of developmental process | developmental process | regulation of DNA biosynthetic process | negative regulation of cell proliferation | cochlea development | potassium ion transmembrane transport | cardiac chamber development | ion channel activity | ion transport | regulation of cell death | circulatory system development | substrate-specific channel activity | signal transduction | regulation of muscle organ development | multicellular organismal process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | synapse | apical plasma membrane | neuron projection | potassium channel complex | somatodendritic compartment | cell body | cell | neuronal cell body | plasma membrane protein complex | distal axon | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | apical part of cell | presynapse | glial cell projection | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | endomembrane system | endoplasmic reticulum membrane | plasma membrane | voltage-gated potassium channel complex | calyx of Held | integral component of plasma membrane | membrane-bounded organelle | astrocyte projection | nucleus | organelle | axon terminus | cell periphery | axon | transmembrane transporter complex | neuron projection terminus | cation channel complex | ion channel complex | cell surface | intracellular | membrane | intrinsic component of plasma membrane