QuickView for TPL2 (gene)

Gene Symbol:

MAP3K8 Homo sapiens

Full name:

mitogen-activated protein kinase kinase kinase 8

Synonyms:

AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, mitogen-activated protein kinase kinase kinase 8, Ewing sarcoma transformant, augmented in rheumatoid arthritis 2, cot (cancer Osaka thyroid) oncogene, proto-oncogene c-Cot, proto-oncogene serine/threoine protein kinase, tumor progression locus 2

Genomic Location:

Chr 10: 30762872-30790767

Description:

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the...

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This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  STAT1_02 ,  NFKAPPAB_01 ,  GTAAACC_MIR2995P ,  STAT1_03 ,  NFKAPPAB65_01 ,  GGGAGGRR_MAZ_Q6 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  CAGCAGG_MIR370 ,  HMGIY_Q6 ,  IRF7_01 ,  CREL_01 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  AAAGGAT_MIR501 ,  CAGCTG_AP4_Q5 ,  AAACCAC_MIR140 ,  GGARNTKYCCA_UNKNOWN ,  NFKB_Q6 ,  NFKB_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-299-3p

miRNA binding sites
(Source: miRecords):

hsa-miR-370 Targeted Genes

Cytogenetic Map:

10p11.23

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