QuickView for TPMT (gene)
- Gene Symbol:
- TPMT
Homo sapiens - Full name:
- thiopurine S-methyltransferase
- Synonyms:
- TPMTD, thiopurine S-methyltransferase, S-adenosyl-L-methionine:thiopurine S-methyltransferase
- Genomic Location:
- Chr 6: 18236521-18263353
- Description:
-
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxi...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
6p22.3
GO Molecular Function
thiopurine S-methyltransferase activity | cofactor binding | S-methyltransferase activity | S-adenosylmethionine-dependent methyltransferase activity | coenzyme binding | catalytic activity | S-adenosyl-L-methionine binding | transferase activity | drug binding | methyltransferase activity
GO Biological Process
thiopurine S-methyltransferase activity | cellular process | S-methyltransferase activity | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular nitrogen compound metabolic process | nitrogen compound metabolic process | methylation | drug metabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | methyltransferase activity | heterocycle metabolic process | cellular metabolic process
GO Cellular Component
cell | cytoplasm | cytosol | intracellular
