QuickView for TPR (gene)

Gene Symbol:

TPR Homo sapiens

Full name:

translocated promoter region, nuclear basket protein

Synonyms:

nucleoprotein TPR, NPC-associated intranuclear protein, megator, nuclear pore complex-associated protein TPR, translocated promoter region (to activated MET oncogene), translocated promoter region protein, tumor potentiating region

Genomic Location:

Chr 1: 184547407-184611080

Description:

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinas...

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This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  GGAMTNNNNNTCCY_UNKNOWN ,  CREB_Q3 ,  ATTCTTT_MIR186 ,  CREB_02 ,  GGGCGGR_SP1_Q6 ,  YGCGYRCGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  E2F_Q2 ,  SMAD_Q6 ,  PAX4_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186

Cytogenetic Map:

1q31.1

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