QuickView for TRIB2 (gene)
- Gene Symbol:
- TRIB2
Homo sapiens - Full name:
- tribbles pseudokinase 2
- Synonyms:
- C5FW, GS3955, TRB2, tribbles homolog 2
- Genomic Location:
- Chr 2: 12774659-12800311
- Description:
-
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiologic...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for let-7 , Predicted Gene Targets for miR-99 , Predicted Gene Targets for miR-125 , Predicted Gene Targets for miR-132 , Predicted Gene Targets for miR-18 , Predicted Gene Targets for miR-193 , Predicted Gene Targets for miR-22 , Predicted Gene Targets for miR-26 , Predicted Gene Targets for miR-330 , Predicted Gene Targets for miR-542-3p
- Cytogenetic Map:
-
2p24.3
GO Molecular Function
kinase binding | protein kinase regulator activity | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | enzyme binding | nucleotide binding | enzyme inhibitor activity | molecular function regulator | catalytic activity | ubiquitin-like protein ligase binding | mitogen-activated protein kinase kinase binding | organic cyclic compound binding | protein binding | transcription factor binding | kinase inhibitor activity | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | enzyme regulator activity | kinase activity | ubiquitin-protein transferase regulator activity | heterocyclic compound binding | small molecule binding
GO Biological Process
negative regulation of phosphorylation | protein kinase regulator activity | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | negative regulation of fat cell differentiation | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | cellular process | regulation of cytokine biosynthetic process | kinase regulator activity | protein kinase inhibitor activity | regulation of proteolysis | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of fat cell differentiation | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | positive regulation of cellular protein catabolic process | enzyme inhibitor activity | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | negative regulation of protein kinase activity | positive regulation of proteolysis involved in cellular protein catabolic process | negative regulation of interleukin-10 biosynthetic process | positive regulation of proteolysis | negative regulation of metabolic process | protein modification process | macromolecule modification | molecular function regulator | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | negative regulation of cytokine production | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of cytokine biosynthetic process | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of proteasomal ubiquitin-dependent protein catabolic process | protein metabolic process | kinase inhibitor activity | regulation of kinase activity | regulation of intracellular signal transduction | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of proteasomal protein catabolic process | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of cellular protein metabolic process | regulation of phosphate metabolic process | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | regulation of developmental process | kinase activity | ubiquitin-protein transferase regulator activity | cellular protein modification process | positive regulation of metabolic process | cellular metabolic process | regulation of ubiquitin-dependent protein catabolic process | negative regulation of cell differentiation | regulation of signaling | macromolecule metabolic process | negative regulation of interleukin-10 production | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | cytoskeleton | intracellular
