QuickView for TRIB3 (gene)
- Gene Symbol:
- TRIB3
Homo sapiens - Full name:
- tribbles pseudokinase 3
- Synonyms:
- C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles homolog 3, TRB-3, neuronal cell death inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, p65-interacting inhibitor of NF-kappaB
- Genomic Location:
- Chr 20: 309308-326203
- Description:
-
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
20p13
| Transcripts Names |
|---|
| NM_021158 |
| XM_017027989 |
| NM_001301190 |
| NM_001301188 |
| NM_001301193 |
| NM_001301196 |
| NM_001301201 |
GO Molecular Function
kinase binding | protein kinase regulator activity | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | enzyme inhibitor activity | carbohydrate derivative binding | molecular function regulator | catalytic activity | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | transcription corepressor activity | mitogen-activated protein kinase kinase binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | kinase inhibitor activity | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | transferase activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | kinase activity | ubiquitin-protein transferase regulator activity | transcription coregulator activity | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | negative regulation of phosphorylation | response to endoplasmic reticulum stress | intracellular signal transduction | regulation of localization | protein kinase regulator activity | response to hormone | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | negative regulation of fat cell differentiation | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | cellular process | regulation of ubiquitin-protein transferase activity | negative regulation of signaling | kinase regulator activity | protein kinase inhibitor activity | negative regulation of nucleic acid-templated transcription | negative regulation of lipid biosynthetic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | intrinsic apoptotic signaling pathway | regulation of protein kinase B signaling | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | positive regulation of protein binding | positive regulation of cellular protein catabolic process | response to stimulus | enzyme inhibitor activity | regulation of fatty acid biosynthetic process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | negative regulation of protein kinase activity | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | response to peptide | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | positive regulation of proteolysis | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | molecular function regulator | regulation of nucleic acid-templated transcription | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | cellular response to peptide hormone stimulus | regulation of MAPK cascade | phosphorus metabolic process | cellular response to insulin stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | cellular response to stress | cellular response to peptide | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | regulation of fatty acid metabolic process | biosynthetic process | negative regulation of protein kinase B signaling | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of proteasomal protein catabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of lipid biosynthetic process | apoptotic signaling pathway | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | protein metabolic process | positive regulation of protein modification process | response to organic substance | kinase inhibitor activity | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | response to insulin | negative regulation of lipid metabolic process | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of proteasomal protein catabolic process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of glucose transmembrane transport | negative regulation of cellular protein metabolic process | gene expression | regulation of phosphate metabolic process | positive regulation of binding | transcription, DNA-templated | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | cellular protein metabolic process | enzyme regulator activity | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | regulation of developmental process | kinase activity | ubiquitin-protein transferase regulator activity | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | response to organonitrogen compound | transcription coregulator activity | heterocycle metabolic process | positive regulation of ubiquitin-protein transferase activity | regulation of lipid metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | negative regulation of fatty acid biosynthetic process | regulation of ubiquitin-dependent protein catabolic process | positive regulation of protein ubiquitination | negative regulation of cell differentiation | negative regulation of fatty acid metabolic process | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane
