Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for TRICK2B (gene)


Gene Symbol:
TNFRSF10B Homo sapiens Homo sapiens
Full name:
TNF receptor superfamily member 10b
Synonyms:
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, tumor necrosis factor receptor superfamily member 10B, Fas-like protein, TNF-related apoptosis-inducing ligand receptor 2, apoptosis inducing protein TRICK2A/2B, apoptosis inducing receptor TRAIL-R2, cytotoxic TRAIL receptor-2, death domain containing receptor for TRAIL/Apo-2L, death receptor 5, p53-regulated DNA damage-inducible cell death receptor(killer), tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor-like protein ZTNFR9
Genomic Location:
Chr 8: 22933591-22982637
Description:
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containin...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 8
8p21.3





GO Molecular Function

TRAIL binding | signaling receptor activity | protein binding

GO Biological Process

regulation of cysteine-type endopeptidase activity | response to endoplasmic reticulum stress | response to cytokine | cell motility | intracellular signal transduction | positive regulation of apoptotic process | regulation of programmed cell death | negative regulation of cellular process | cellular response to tumor necrosis factor | positive regulation of phosphate metabolic process | cellular process | localization | extrinsic apoptotic signaling pathway | negative regulation of signaling | positive regulation of protein kinase activity | negative regulation of apoptotic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | intrinsic apoptotic signaling pathway | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | response to stimulus | positive regulation of NIK/NF-kappaB signaling | cellular response to mechanical stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | positive regulation of cysteine-type endopeptidase activity | programmed cell death | positive regulation of proteolysis | extrinsic apoptotic signaling pathway via death domain receptors | activation of protein kinase activity | leukocyte migration | locomotion | apoptotic process | regulation of signal transduction | cell migration | regulation of peptidase activity | regulation of catalytic activity | regulation of phosphorylation | regulation of extrinsic apoptotic signaling pathway | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of hydrolase activity | negative regulation of extrinsic apoptotic signaling pathway | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | regulation of apoptotic signaling pathway | activation of NF-kappaB-inducing kinase activity | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | apoptotic signaling pathway | positive regulation of molecular function | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | response to mechanical stimulus | regulation of intracellular signal transduction | cell surface receptor signaling pathway | activation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of programmed cell death | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | positive regulation of cell death | cell death | positive regulation of programmed cell death | positive regulation of kinase activity | tumor necrosis factor-mediated signaling pathway | regulation of phosphate metabolic process | regulation of cell communication | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of phosphorylation | regulation of endopeptidase activity | NIK/NF-kappaB signaling | positive regulation of metabolic process | immune system process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | negative regulation of cell death | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of signaling | signal transduction | regulation of signaling | regulation of phosphorus metabolic process

GO Cellular Component

cell | plasma membrane | cell periphery | cell surface | intracellular | membrane