QuickView for TRIM21 (gene)

Gene Symbol:

TRIM21 Homo sapiens

Full name:

tripartite motif containing 21

Synonyms:

RNF81, RO52, Ro/SSA, SSA, SSA1, E3 ubiquitin-protein ligase TRIM21, 52 kDa Ro protein, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, RING finger protein 81, RING-type E3 ubiquitin transferase TRIM21, SS-A, Sicca syndrome antigen A, Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro), ro(SS-A), sjoegren syndrome type A antigen, tripartite motif-containing protein 21

Genomic Location:

Chr 11: 4362703-4371502

Description:

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes t...

View Full Description

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  IRF1_Q6 ,  IRF_Q6 ,  IRF7_01 ,  ISRE_01 ,  STTTCRNTTT_IRF_Q6

Cytogenetic Map:

11p15.4

search → result