QuickView for TRIM25 (gene)

Gene Symbol:

TRIM25 Homo sapiens

Full name:

tripartite motif containing 25

Synonyms:

EFP, RNF147, Z147, ZNF147, E3 ubiquitin/ISG15 ligase TRIM25, RING finger protein 147, RING-type E3 ubiquitin transferase, RING-type E3 ubiquitin transferase TRIM25, estrogen-responsive finger protein, tripartite motif protein TRIM25, tripartite motif-containing protein 25, ubiquitin/ISG15-conjugating enzyme TRIM25, zinc finger protein 147 (estrogen-responsive finger protein), zinc finger protein-147

Genomic Location:

Chr 17: 52320269-52346408

Description:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein...

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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  STAT6_02 ,  GGGAGGRR_MAZ_Q6 ,  STAT5B_01 ,  GGGCGGR_SP1_Q6 ,  STAT_01 ,  AGGGCAG_MIR18A ,  TTCYNRGAA_STAT5B_01 ,  TCCATTKW_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-150

Cytogenetic Map:

17q22

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