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QuickView for TRIP12;jsessionid=704E499B4FE4E691F2F70BFE2E967E00 (gene)


Gene Symbol:
TRIP12 Homo sapiens Homo sapiens
Full name:
thyroid hormone receptor interactor 12
Synonyms:
MRD49, TRIP-12, ULF, E3 ubiquitin-protein ligase TRIP12, E3 ubiquitin-protein ligase for Arf, HECT-type E3 ubiquitin transferase TRIP12, TR-interacting protein 12, probable E3 ubiquitin-protein ligase TRIP12, thyroid receptor interacting protein 12
Genomic Location:
Chr 2: 230340174-230494899
Description:
The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q36.3





GO Molecular Function

hormone receptor binding | signaling receptor binding | thyroid hormone receptor binding | catalytic activity | ubiquitin-like protein transferase activity | nuclear hormone receptor binding | protein binding | transcription factor binding | ubiquitin-protein transferase activity | transferase activity

GO Biological Process

proteolysis | negative regulation of cellular process | regulation of organelle organization | negative regulation of DNA metabolic process | regulation of DNA repair | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of embryonic development | regulation of histone modification | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | negative regulation of histone H2A K63-linked ubiquitination | negative regulation of DNA repair | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | response to stress | regulation of protein ubiquitination | regulation of double-strand break repair | cellular protein catabolic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | macromolecule modification | DNA repair | regulation of histone ubiquitination | regulation of cellular response to stress | nitrogen compound metabolic process | cellular response to DNA damage stimulus | cellular response to stress | protein catabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | negative regulation of double-strand break repair | regulation of cellular protein metabolic process | regulation of cellular metabolic process | regulation of protein metabolic process | negative regulation of protein ubiquitination | protein polyubiquitination | protein metabolic process | protein ubiquitination | DNA metabolic process | cellular macromolecule catabolic process | metabolic process | ubiquitin-protein transferase activity | negative regulation of protein polyubiquitination | regulation of protein K63-linked ubiquitination | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of cellular protein metabolic process | protein modification by small protein conjugation or removal | regulation of chromosome organization | ubiquitin-dependent protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | negative regulation of chromosome organization | cellular protein metabolic process | negative regulation of protein K63-linked ubiquitination | regulation of developmental process | cellular protein modification process | heterocycle metabolic process | cellular metabolic process | modification-dependent protein catabolic process | regulation of cellular component organization | macromolecule metabolic process | regulation of chromatin organization

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | nucleoplasm | nuclear speck | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular