QuickView for TRIP4;jsessionid=5AF227365818A7BACC2E502D0A8408D7 (gene)

Gene Symbol:

TRIP4 Homo sapiens

Full name:

thyroid hormone receptor interactor 4

Synonyms:

ASC-1, ASC1, HsT17391, MDCDC, SMABF1, ZC2HC5, activating signal cointegrator 1, TR-interacting protein 4, TRIP-4, thyroid receptor-interacting protein 4, zinc finger, C2HC5-type

Genomic Location:

Chr 15: 62467073-62534555

Description:

This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, wh...

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This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HEN1_01 ,  HEB_Q6 ,  CAGCTG_AP4_Q5

Cytogenetic Map:

15q22.31

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