QuickView for TRPM7 (gene)

Gene Symbol:

TRPM7 Homo sapiens

Full name:

transient receptor potential cation channel subfamily M member 7

Synonyms:

ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, transient receptor potential cation channel subfamily M member 7, LTRPC ion channel family member 7, channel-kinase 1, long transient receptor potential channel 7, transient receptor potential-phospholipase C-interacting kinase

Genomic Location:

Chr 15: 48639782-48766286

Description:

This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion h...

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This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATAAGCT_MIR21 ,  AAGCCAT_MIR135A_MIR135B ,  TCANNTGAY_SREBP1_01 ,  ARNT_01 ,  CACGTG_MYC_Q2 ,  ZF5_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ARNT_02 ,  STAT_Q6 ,  TATAAA_TATA_01 ,  CDPCR3HD_01 ,  SREBP1_01 ,  CAGGTA_AREB6_01 ,  AP4_01 ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  AREB6_01 ,  E2F1_Q3_01 ,  NKX25_02 ,  TTCYNRGAA_STAT5B_01 ,  ACCATTT_MIR522

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

15q21.2

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