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QuickView for TRPV4 (gene)


Gene Symbol:
TRPV4 Homo sapiens Homo sapiens
Full name:
transient receptor potential cation channel subfamily V member 4
Synonyms:
BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC, transient receptor potential cation channel subfamily V member 4, OSM9-like transient receptor potential channel 4, osm-9-like TRP channel 4, osmosensitive transient receptor potential channel 4, transient receptor potential protein 12, vanilloid receptor-like channel 2, vanilloid receptor-related osmotically activated channel
Genomic Location:
Chr 12: 108705277-108755595
Description:
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the c...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12
12q24.11





GO Molecular Function

actin binding | kinase binding | actin filament binding | stretch-activated, cation-selective, calcium channel activity | cation binding | passive transmembrane transporter activity | alpha-tubulin binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | protein-containing complex binding | ribonucleotide binding | transmembrane transporter activity | lipid binding | osmosensor activity | nucleotide binding | ion gated channel activity | carbohydrate derivative binding | beta-tubulin binding | protein domain specific binding | ATP binding | protein kinase C binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | cation transmembrane transporter activity | signaling receptor activity | purine nucleotide binding | transporter activity | mechanosensitive ion channel activity | calcium ion transmembrane transporter activity | identical protein binding | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | metal ion transmembrane transporter activity | microtubule binding | cation channel activity | inorganic cation transmembrane transporter activity | purine ribonucleotide binding | tubulin binding | adenyl ribonucleotide binding | channel activity | drug binding | calcium channel activity | calmodulin binding | metal ion binding | ion channel activity | heterocyclic compound binding | substrate-specific channel activity | small molecule binding | SH2 domain binding

GO Biological Process

response to extracellular stimulus | regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | regulation of supramolecular fiber organization | positive regulation of locomotion | blood vessel endothelial cell delamination | response to nutrient levels | actin filament-based process | regulation of microtubule polymerization or depolymerization | hyperosmotic response | positive regulation of cellular component organization | regulation of neurogenesis | regulation of cell development | regulation of localization | hormone secretion | actin cytoskeleton organization | establishment of localization | regulation of aerobic respiration | regulation of immune system process | response to hormone | regulation of chemokine (C-X-C motif) ligand 1 production | negative regulation of cellular process | negative regulation of RNA biosynthetic process | bone development | microtubule cytoskeleton organization | cell differentiation | negative regulation of fat cell differentiation | nervous system development | cellular chemical homeostasis | endochondral bone morphogenesis | stretch-activated, cation-selective, calcium channel activity | neurogenesis | glucose homeostasis | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | adaptive thermogenesis | microtubule-based process | calcium ion import | cellular process | secretion | peptide hormone secretion | positive regulation of macrophage migration | regulation of cell motility | localization | cellular homeostasis | passive transmembrane transporter activity | metal ion transport | diet induced thermogenesis | delamination | negative regulation of nucleic acid-templated transcription | regulation of chemotaxis | regulation of response to osmotic stress | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of fat cell differentiation | regulation of cell differentiation | cell junction assembly | regulation of cellular process | microtubule polymerization | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | positive regulation of protein complex disassembly | positive regulation of cellular protein metabolic process | signal transduction involved in regulation of aerobic respiration | cellular component organization | calcium ion homeostasis | positive regulation of chemokine (C-C motif) ligand 5 production | regulation of microtubule depolymerization | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | ion gated channel activity | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | response to salt stress | response to stress | cortical microtubule organization | negative regulation of neuron projection development | multicellular organismal homeostasis | response to peptide | cartilage development involved in endochondral bone morphogenesis | supramolecular fiber organization | divalent metal ion transport | secretion by cell | positive regulation of cytokine secretion | response to temperature stimulus | regulation of protein transport | blood circulation | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | cartilage development | regulation of peptide transport | regulation of cell adhesion | cell-cell signaling | hypotonic response | osmosensory signaling pathway | metal ion homeostasis | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | water homeostasis | regulation of cellular response to stress | response to nitrogen compound | system development | regulation of signal transduction | positive regulation of organelle organization | multicellular organism development | calcium ion transmembrane transport | regulation of MAPK cascade | positive regulation of inflammatory response | actin filament organization | regulation of granulocyte chemotaxis | regulation of phosphorylation | regulation of hormone levels | ion transmembrane transport | regulation of protein complex disassembly | regulation of neuron differentiation | regulation of gene expression | positive regulation of chemotaxis | positive regulation of secretion | organic substance transport | cellular response to stress | cation transmembrane transporter activity | cellular response to heat | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | negative regulation of brown fat cell differentiation | animal organ morphogenesis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of JNK cascade | regulation of vascular permeability | peptide transport | protein polymerization | positive regulation of intracellular signal transduction | cellular hypotonic salinity response | regulation of cellular component movement | regulation of transcription by RNA polymerase II | mechanosensitive ion channel activity | calcium ion transmembrane transporter activity | positive regulation of protein depolymerization | ion transmembrane transporter activity | positive regulation of cell migration | response to osmotic stress | regulation of cellular protein metabolic process | positive regulation of monocyte chemotactic protein-1 production | cellular protein-containing complex assembly | positive regulation of chemokine production | positive regulation of macrophage chemotaxis | cation homeostasis | regulation of leukocyte migration | energy homeostasis | negative regulation of cell-cell adhesion | peptide secretion | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | skeletal system morphogenesis | positive regulation of leukocyte chemotaxis | cytoplasmic microtubule organization | positive regulation of cytoskeleton organization | vasopressin secretion | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | bone morphogenesis | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | regulation of protein depolymerization | regulation of microtubule-based process | regulation of cytokine secretion | cation transmembrane transport | protein-containing complex assembly | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | negative regulation of cell projection organization | regulation of cellular respiration | response to mechanical stimulus | metal ion transmembrane transporter activity | cellular response to osmotic stress | regulation of intracellular signal transduction | response to insulin | positive regulation of vascular permeability | anatomical structure development | metabolic process | positive regulation of supramolecular fiber organization | cell-cell junction assembly | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | actin cytoskeleton reorganization | amide transport | chemical homeostasis | calcium ion transport | regulation of secretion | positive regulation of interleukin-6 production | hormone transport | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of neuron differentiation | regulation of protein secretion | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | response to heat | ion homeostasis | cellular response to salt stress | regulation of phosphate metabolic process | cytoskeleton organization | inorganic cation transmembrane transport | microtubule polymerization or depolymerization | positive regulation of cytokine production | regulation of JNK cascade | regulation of brown fat cell differentiation | positive regulation of MAPK cascade | positive regulation of protein transport | cation channel activity | hyperosmotic salinity response | regulation of stress-activated MAPK cascade | regulation of cell communication | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | regulation of transcription, DNA-templated | positive regulation of phosphorylation | regulation of cell size | regulation of cytokine production | anatomical structure morphogenesis | cation transport | channel activity | regulation of nervous system development | regulation of developmental process | developmental process | organelle organization | calcium channel activity | positive regulation of macrophage inflammatory protein 1 alpha production | cortical cytoskeleton organization | regulation of monocyte chemotactic protein-1 production | regulation of chemokine production | negative regulation of transcription by RNA polymerase II | regulation of transport | regulation of cell-cell adhesion | multicellular organismal water homeostasis | response to dietary excess | signal release | response to organonitrogen compound | cellular metal ion homeostasis | hypotonic salinity response | regulation of macrophage chemotaxis | positive regulation of microtubule depolymerization | cellular hypotonic response | ion channel activity | regulation of generation of precursor metabolites and energy | positive regulation of metabolic process | ion transport | regulation of cell projection organization | skeletal system development | regulation of protein localization | positive regulation of cell motility | negative regulation of cell development | regulation of interleukin-6 production | regulation of inflammatory response | carbohydrate homeostasis | divalent inorganic cation homeostasis | substrate-specific channel activity | regulation of microtubule cytoskeleton organization | negative regulation of cell differentiation | regulation of cellular component organization | cell volume homeostasis | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | positive regulation of chemokine (C-X-C motif) ligand 1 production | negative regulation of neurogenesis | positive regulation of interleukin-6 secretion | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | integral component of membrane | intracellular membrane-bounded organelle | apical plasma membrane | neuron projection | ruffle | adherens junction | cell projection membrane | focal adhesion | cytoplasmic vesicle | actin-based cell projection | cell | distal axon | intrinsic component of membrane | ruffle membrane | lamellipodium | microtubule | cytoplasm | cortical cytoskeleton | cytoplasmic microtubule | cell-substrate junction | intracellular organelle | actin cytoskeleton | endoplasmic reticulum | leading edge membrane | apical part of cell | cell projection | endomembrane system | plasma membrane | cell leading edge | cilium | vesicle | microtubule cytoskeleton | cytoplasmic region | site of polarized growth | integral component of plasma membrane | cortical actin cytoskeleton | cell cortex | membrane-bounded organelle | filopodium | organelle | cell periphery | axon | cell-substrate adherens junction | growth cone | intracellular vesicle | cell surface | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex | intrinsic component of plasma membrane