QuickView for TSC1 (gene)

Gene Symbol:

TSC1 Homo sapiens

Full name:

TSC complex subunit 1

Synonyms:

LAM, TSC, hamartin, tuberous sclerosis 1 protein, tumor suppressor

Genomic Location:

Chr 9: 134756557-134809841

Description:

This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.

This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  RTAAACA_FREAC2_01 ,  TTTGCAC_MIR19A_MIR19B ,  TFIIA_Q6 ,  OCT1_B ,  TTANTCA_UNKNOWN ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  ATCMNTCCGY_UNKNOWN ,  CAGTGTT_MIR141_MIR200A ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTAWWWATA_RSRFC4_Q2 ,  GCCATNTTG_YY1_Q6 ,  OCT_C ,  ACTGTGA_MIR27A_MIR27B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  COMP1_01 ,  GGGAGGRR_MAZ_Q6 ,  GGGNRMNNYCAT_UNKNOWN ,  STAT_Q6 ,  TATAAA_TATA_01 ,  EVI1_03 ,  OCT1_Q6 ,  YY1_Q6 ,  MEF2_01 ,  YYCATTCAWW_UNKNOWN ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  CAGCTTT_MIR320 ,  EVI1_05 ,  AAGWWRNYGGC_UNKNOWN ,  CCAWNWWNNNGGC_UNKNOWN ,  FOXO1_01 ,  USF_01 ,  HMEF2_Q6 ,  OCT1_02 ,  GATGKMRGCG_UNKNOWN ,  TTGTTT_FOXO4_01 ,  YY1_02 ,  IRF7_01 ,  TATA_01 ,  KMCATNNWGGA_UNKNOWN ,  TGATTTRY_GFI1_01 ,  CTTTGT_LEF1_Q2 ,  TBP_01 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-421 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

9q34.13

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