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QuickView for TTN (gene)


Gene Symbol:
TTN Homo sapiens Homo sapiens
Full name:
titin
Synonyms:
CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, SALMY, TMD, titin, connectin, rhabdomyosarcoma antigen MU-RMS-40.14
Genomic Location:
Chr 2: 179098962-179380395
Description:
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Danio rerio Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q31.2





GO Molecular Function

structural molecule activity | actin binding | protein self-association | kinase binding | actin filament binding | cation binding | protein kinase binding | enzyme binding | telethonin binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | alpha-actinin binding | muscle alpha-actinin binding | catalytic activity | ATP binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | structural molecule activity conferring elasticity | calcium ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | protease binding | calmodulin binding | actinin binding | metal ion binding | heterocyclic compound binding | structural constituent of muscle | small molecule binding

GO Biological Process

mitotic chromosome condensation | heart process | actin filament-based process | exocytosis | detection of stimulus | muscle tissue development | intracellular signal transduction | regulation of localization | peptidyl-amino acid modification | actin cytoskeleton organization | establishment of localization | platelet degranulation | response to metal ion | protein kinase A signaling | cell differentiation | striated muscle cell development | peptidyl-tyrosine phosphorylation | positive regulation of protein secretion | cardiac cell development | cellular process | secretion | localization | sarcomere organization | heart morphogenesis | response to inorganic substance | tissue development | actin filament-based movement | muscle structure development | muscle cell differentiation | regulation of cellular process | regulation of metabolic process | heart contraction | cellular component organization | actin-mediated cell contraction | regulation of peptide secretion | muscle contraction | muscle organ morphogenesis | response to stimulus | muscle cell development | chromosome segregation | actin-myosin filament sliding | skeletal muscle myosin thick filament assembly | cardiac muscle tissue development | muscle tissue morphogenesis | response to muscle stretch | protein serine/threonine kinase activity | supramolecular fiber organization | secretion by cell | regulation of protein transport | blood circulation | cellular component assembly | protein modification process | regulation of peptide transport | macromolecule modification | muscle fiber development | positive regulation of peptide secretion | detection of abiotic stimulus | organelle assembly | system development | nitrogen compound metabolic process | multicellular organism development | sister chromatid segregation | phosphorus metabolic process | actin filament organization | regulation of catalytic activity | regulation of phosphorylation | myosin filament organization | regulation of gene expression | positive regulation of secretion | cell cycle | chromosome condensation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | muscle filament sliding | cardiocyte differentiation | vesicle-mediated transport | striated muscle myosin thick filament assembly | cardiac muscle hypertrophy | cardiac myofibril assembly | regulation of cellular protein metabolic process | cardiac muscle cell development | phosphorylation | actomyosin structure organization | regulated exocytosis | cellular protein-containing complex assembly | myosin filament assembly | cardiac muscle fiber development | detection of muscle stretch | protein phosphorylation | phosphate-containing compound metabolic process | nuclear chromosome segregation | skeletal myofibril assembly | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | skeletal muscle thin filament assembly | heart development | positive regulation of establishment of protein localization | regulation of protein phosphorylation | positive regulation of transport | striated muscle contraction | striated muscle cell differentiation | protein tyrosine kinase activity | protein-containing complex assembly | protein metabolic process | regulation of establishment of protein localization | tissue morphogenesis | regulation of kinase activity | response to mechanical stimulus | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | sarcomerogenesis | regulation of secretion | protein kinase activity | organic substance metabolic process | animal organ development | regulation of protein secretion | myofibril assembly | regulation of phosphate metabolic process | DNA packaging | cytoskeleton organization | mitotic nuclear division | detection of mechanical stimulus | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | cardiac muscle cell differentiation | signaling | cell development | cellular protein metabolic process | anatomical structure morphogenesis | kinase activity | developmental process | organelle organization | cellular protein modification process | regulation of transport | DNA conformation change | response to calcium ion | positive regulation of metabolic process | chromosome organization | cardiac muscle contraction | cellular metabolic process | regulation of protein localization | circulatory system development | muscle hypertrophy | mitotic sister chromatid segregation | muscle organ development | muscle system process | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

condensed nuclear chromosome | supramolecular fiber | chromosome | intracellular membrane-bounded organelle | sarcomere | cell | nuclear lumen | A band | M band | myofibril | cytoplasm | striated muscle thin filament | intracellular organelle | actin cytoskeleton | contractile fiber | nuclear chromosome | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | I band | extracellular space | membrane-enclosed lumen | Z disc | cytosol | cytoskeleton | intracellular | supramolecular complex | condensed chromosome