QuickView for TUSC3 (gene)

Gene Symbol:

TUSC3 Homo sapiens

Full name:

tumor suppressor candidate 3

Synonyms:

D8S1992, M33, MRT22, MRT7, N33, OST3A, tumor suppressor candidate 3, magnesium uptake/transporter TUSC3, oligosaccharyltransferase 3 homolog A, putative prostate cancer tumor suppressor

Genomic Location:

Chr 8: 15442101-15666366

Description:

This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. Th...

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This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  MIF1_01 ,  TEL2_Q6 ,  VDR_Q6 ,  CYTAGCAAY_UNKNOWN ,  MAF_Q6 ,  RFX1_01 ,  CACCCBINDINGFACTOR_Q6 ,  GGGYGTGNY_UNKNOWN ,  ETS2_B ,  NERF_Q2 ,  MGGAAGTG_GABP_B ,  RNGTGGGC_UNKNOWN ,  P300_01

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Cytogenetic Map:

8p22

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