QuickView for TXNIP (gene)
- Gene Symbol:
- TXNIP
Homo sapiens - Full name:
- thioredoxin interacting protein
- Synonyms:
- ARRDC6, EST01027, HHCPA78, THIF, VDUP1, thioredoxin-interacting protein, thioredoxin binding protein 2, upregulated by 1,25-dihydroxyvitamin D-3, vitamin D3 up-regulated protein 1
- Genomic Location:
- Chr 1: 144149939-144153882
- Description:
-
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxyge...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1q21.1
GO Molecular Function
enzyme binding | enzyme inhibitor activity | molecular function regulator | ubiquitin-like protein ligase binding | protein binding | ubiquitin protein ligase binding | enzyme regulator activity
GO Biological Process
RNA metabolic process | negative regulation of cell division | positive regulation of apoptotic process | regulation of programmed cell death | cellular response to tumor cell | establishment of localization | response to hormone | negative regulation of cellular process | negative regulation of RNA biosynthetic process | response to metal ion | cell differentiation | response to drug | response to antibiotic | intracellular transport | cellular process | localization | protein transport | response to progesterone | response to estradiol | negative regulation of nucleic acid-templated transcription | macromolecule localization | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | protein import into nucleus | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | regulation of cell division | response to stimulus | enzyme inhibitor activity | response to stress | intracellular protein transport | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | protein localization to nucleus | response to glucose | cellular localization | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular biosynthetic process | molecular function regulator | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | negative regulation of catalytic activity | regulation of catalytic activity | regulation of gene expression | platelet-derived growth factor receptor signaling pathway | organic substance transport | response to ketone | response to lipid | cell cycle | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | peptide transport | regulation of transcription by RNA polymerase II | response to oxidative stress | protein localization to organelle | import into nucleus | epidermal cell differentiation | biosynthetic process | response to tumor cell | aromatic compound biosynthetic process | epidermis development | response to toxic substance | skin development | keratinocyte differentiation | protein import | cell communication | regulation of cellular metabolic process | response to monosaccharide | regulation of RNA metabolic process | response to organic substance | response to mechanical stimulus | establishment of protein localization to organelle | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | amide transport | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | nuclear transport | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | gene expression | positive regulation of programmed cell death | establishment of protein localization | transcription, DNA-templated | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | protein localization | enzyme regulator activity | cellular macromolecule localization | cellular macromolecule biosynthetic process | response to biotic stimulus | nucleocytoplasmic transport | developmental process | negative regulation of transcription by RNA polymerase II | epithelial cell differentiation | heterocycle metabolic process | response to calcium ion | transmembrane receptor protein tyrosine kinase signaling pathway | cellular metabolic process | regulation of cell death | response to carbohydrate | response to steroid hormone | signal transduction | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
mitochondrial intermembrane space | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | membrane-enclosed lumen | cytosol | intracellular
