QuickView for TXNRD1 (gene)

Gene Symbol:

TXNRD1 Homo sapiens

Full name:

thioredoxin reductase 1

Synonyms:

GRIM-12, TR, TR1, TRXR1, TXNR, thioredoxin reductase 1, cytoplasmic, KM-102-derived reductase-like factor, gene associated with retinoic and IFN-induced mortality 12 protein, gene associated with retinoic and interferon-induced mortality 12 protein, oxidoreductase, testis tissue sperm-binding protein Li 46a, thioredoxin reductase GRIM-12, thioredoxin reductase TR1

Genomic Location:

Chr 12: 103133689-103268192

Description:

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox...

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The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  HOXA3_01 ,  GGGYGTGNY_UNKNOWN ,  CTCAGGG_MIR125B_MIR125A ,  GGGCGGR_SP1_Q6 ,  NRF2_Q4 ,  CTTTGT_LEF1_Q2 ,  TCF11MAFG_01 ,  TCF11_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-205

Cytogenetic Map:

12q23.3

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