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QuickView for TYK2 (gene)

Gene Symbol:
TYK2 Homo sapiens Homo sapiens
Full name:
tyrosine kinase 2
IMD35, JTK1, non-receptor tyrosine-protein kinase TYK2
Genomic Location:
Chr 19: 10322209-10352211
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signal...
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19

GO Molecular Function

hormone receptor binding | type 1 angiotensin receptor binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | growth hormone receptor binding | purine nucleotide binding | angiotensin receptor binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding

GO Biological Process

response to cytokine | intracellular signal transduction | peptidyl-amino acid modification | cellular response to type I interferon | defense response | peptidyl-tyrosine phosphorylation | cellular process | response to type I interferon | regulation of cellular process | response to stimulus | response to stress | protein modification process | response to interleukin-12 | interleukin-12-mediated signaling pathway | macromolecule modification | nitrogen compound metabolic process | phosphorus metabolic process | cytokine-mediated signaling pathway | cellular response to cytokine stimulus | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | protein tyrosine kinase activity | protein metabolic process | response to organic substance | cell surface receptor signaling pathway | metabolic process | immune response | protein kinase activity | organic substance metabolic process | interleukin-23-mediated signaling pathway | interleukin-27-mediated signaling pathway | type I interferon signaling pathway | non-membrane spanning protein tyrosine kinase activity | signaling | cellular protein metabolic process | kinase activity | cellular protein modification process | innate immune response | immune system process | cellular metabolic process | cellular response to organic substance | signal transduction | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cytosol | cytoskeleton | intracellular