QuickView for Tbx3 (gene)

Gene Symbol:

TBX3 Homo sapiens

Full name:

T-box 3

Synonyms:

TBX3-ISO, UMS, XHL, T-box transcription factor TBX3, T-box protein 3, bladder cancer related protein XHL

Genomic Location:

Chr 12: 113592442-113606352

Description:

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mu...

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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  HEN1_01 ,  AAAYWAACM_HFH4_01 ,  TGAGATT_MIR216 ,  E2F_Q6_01 ,  CTTTGA_LEF1_Q2 ,  CTCNANGTGNY_UNKNOWN ,  WHN_B ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  CDPCR3HD_01 ,  CDP_02 ,  TATA_C ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  CTTTAAR_UNKNOWN ,  AP2_Q3 ,  E2F_03 ,  E2F_Q4_01 ,  TTGTTT_FOXO4_01 ,  ATATGCA_MIR448 ,  HEN1_02 ,  T3R_Q6 ,  E2F1_Q3 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  EGR1_01 ,  PAX3_B ,  CAGCTG_AP4_Q5 ,  AAACCAC_MIR140 ,  E2F_Q3 ,  TCF1P_Q6 ,  E2F_Q3_01 ,  CACTTTG_MIR520G_MIR520H ,  SP1_Q2_01 ,  GGGTGGRR_PAX4_03 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-140

Cytogenetic Map:

12q24.21

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