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QuickView for Temafloxacin (compound)

Summary
General Info

PubChem

PubChem Compound 11640304

PubChem Compound 11640304

Name:	temafloxacin
PubChem Compound ID:	11640304
Molecular formula:	C₂₁H₁₈F₃N₃O₃
Molecular weight:	417.381 g/mol

DrugBank

Identification

Name:	temafloxacin
Name (isomeric):	DB01405
Drug Type:	small molecule
Synonyms:	Temafloxacin hydrochloride; Temafloxacinum [latin]; Temafloxacina [spanish]; Temafloxacine [french]
Brand:	Omniflox
Category:	Anti-Bacterial Agents
CAS number:	108319-06-8

Pharmacology

Indication:	For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.
Pharmacology:	Temafloxacin (marketed by Abbott Laboratories as Omniflox), is a fluoroquinolone antibiotic drug which was withdrawn from sale in the U.S. shortly after its approval in 1992 because of serious adverse reactions resulting in three deaths. Flouroquinolones such as lomefloxacin possess excellent activity against gram-negative aerobic bacteria such as ... show more » Temafloxacin (marketed by Abbott Laboratories as Omniflox), is a fluoroquinolone antibiotic drug which was withdrawn from sale in the U.S. shortly after its approval in 1992 because of serious adverse reactions resulting in three deaths. Flouroquinolones such as lomefloxacin possess excellent activity against gram-negative aerobic bacteria such as E.coli and Neisseria gonorrhoea as well as gram-positive bacteria including S. pneumoniae and Staphylococcus aureus. They also posses effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter. show less «
Mechanism of Action:	The bactericidal action of temafloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential targe... show more » The bactericidal action of temafloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited. show less «
Absorption:	Studies in healthy volunteers indicate that the average bioavailability of temafloxacin exceeds 90%, with little intersubject variability.
Biotransformation:	Hepatic.
Half Life:	Approximately 8 hours in patients with normal renal function.
Toxicity:	Severe adverse reactions, including allergic reactions and hemolytic anemia, developed in about fifty patients during the first four months of its use, leading to three patient deaths
Affected organisms:	Enteric bacteria and other eubacteria

Interactions

Drug interaction:

Magnesium	Formation of non-absorbable complexes
Iron Dextran	Formation of non-absorbable complexes
Calcium	Formation of non-absorbable complexes

Targets

DNA gyrase subunit A

DNA topoisomerase 4 subunit A

Enzymes

Cytochrome P450 1A2