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QuickView for Terbutaline (compound)

Name: Terbutaline
PubChem Compound ID: 31620
Description: A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
Molecular formula: C24H40N2O10S
Molecular weight: 548.648 g/mol
Terbutaline sulfate [USAN:JAN]; 98225-49-1; 1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol sulphate; Bricanyl; BENZYL ALCOHOL, alpha-((tert-BUTYLAMINO)METHYL)-3,5-DIHYDROXY-, SULFATE (2:1); Terbutaline sulfate; 1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, sulfate (2:1) (salt); 23031-25-6; (+-)-alpha-((tert-Butylamino)methyl)-3,5-dihydroxybenzyl alcohol sulfate (2:1) (salt); KWD 2019.
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Name: Terbutaline
Name (isomeric): DB00871
Drug Type: small molecule
Description: A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
Terbutalina [Dcit]; Terbutaline Sulfate; Terbutalin; Terbutalino [INN-Spanish]; Terbutalinum [INN-Latin]
Brand: Bricaril, Bricyn, Brican, Brethine, Bricar, Bricanyl, Brethaire
Category: Sympathomimetic, Tocolytic Agents, Adrenergic beta-Agonists, Sympathomimetics, Bronchodilator Agents
CAS number: 23031-25-6
Indication: For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Also used acute IV and sub-Q therapy in selected women to inhibit uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial.
Terbutaline is a relatively selective beta2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on beta2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline appears to have a greater stimulatin...
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Mechanism of Action:
The pharmacologic effects of terbutaline are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial sm...
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Absorption: Approximately 30-50% if administered orally and well absorbed subcutaneously.
Route of elimination: About 90% of the drug was excreted in the urine at 96 hours after subcutaneous administration, with about 60% of this being unchanged drug. It appears that the sulfate conjugate is a major metabolite of terbutaline and urinary excretion is the primary route of elimination
Half Life: 5.5-5.9 hours
Clearance: 311 +/- 112 mL/min
Toxicity: Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
Affected organisms: Humans and other mammals
Drug interaction:
PhenelzineIncreased arterial pressure
AlseroxylonIncreased arterial pressure
ReserpineIncreased arterial pressure
ClomipramineThe tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of terbutaline.
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