Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Testosterone (compound)


PubChem
Name: Testosterone
PubChem Compound ID: 10067623
Description: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Molecular formula: C19H28O5S
Molecular weight: 368.489 g/mol
DrugBank
Identification
Name: Testosterone
Name (isomeric): DB00624
Drug Type: small molecule
Description: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Synonyms:
Testosterone Hydrate; TES; Testosteronum [INN-Latin]; Trans-Testosterone; Testosterone Cypionate; Testosterone Enanthate; Testosteron; Testosterona [INN-Spanish]; Testostosterone
Brand: Sustanone, Bio-T-Gel, Testred Cypionate 200, Cristerone T, Andronate 100, Relibra, Everone 200, Scheinpharm Testone-Cyp, Andro L.A. 200, Depotest, Orquisteron, Androlin, Malogen, Aquaspension Injection, Sustanon, Oreton F, Primotest, Neotestis, Testoderm Tts, Androgel, Striant, Testoviron, Virosterone, Testolin, Oreton-F, Android 5, Testoject-50, Homosteron, Andronaq, Beta Testosterone, Androsorb, Methyltestosterone, Andro 100, Testryl, Perandren, Testim, Andropository 200, Andriol, Virilon IM, Delatest, Testoviron T, Virormone, Testrone, Testobase, Testogel, CDB 111C, Delatestryl, Malestrone, Libigel, Oreton Methyl, Testoderm, Geno-Cristaux Gremy, T-Cypionate, Synandrol F, Android 10, Testaqua, Depo-Testosterone Cypionate, Testoviron Schering, Neo-Hombreol F, Homosterone, Malogen in Oil, Depo-Testosterone, Testred, Teslen, Percutacrine Androgenique, Andryl 200, Primoteston, Andro, Andropatch, Testandrone, Testopel Pellets, Malerone, Androderm, Neo-Testis, Testamone 100, Andrusol, Android 25, Testosteroid, Testopropon, Sustason 250, Virilon, Mertestate, Testro Aq, Cristerona T, Oreton, Andronate 200, Metandren, Testrin-P.A, Testiculosterone
Brand name mixture:
Anadiol Inj Liq(Estradiol Benzoate + Estradiol Enanthate + Testosterone Enanthate), Component E-H Implants with Tylan(Estradiol Benzoate + Testosterone Propionate + Tylosin Tartrate), Component E-H Implants(Estradiol Benzoate + Testosterone Propionate), Uni-Bol(Estradiol Benzoate + Estradiol Enanthate + Testosterone Enanthate), Neo Pause Injecti...
show more »
Category: Androgens
CAS number: 58-22-0
Pharmacology
Indication: To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone.
Pharmacology:
Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted from the testes of males. In females, it is produced in the ovaries, adrenal glands and by conversion of adrostenedione in the periphery. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health ...
show more »
Mechanism of Action:
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen r...
show more »
Absorption: Approximately 10% of the testosterone dose applied on the skin surface is absorbed into systemic circulation
Protein binding: 40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins.
Biotransformation: Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).
Route of elimination: About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6% of a dose is excreted in the feces, mostly in the unconjugated form.
Half Life: 10-100 minutes
Toxicity: Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
AnisindioneThe androgen may increase the anticoagulant effect of anisindione.
CyclosporineThe androgen, Testosterone, may increase the hepatotoxicity of Cyclosporine. Testosterone may also elevate serum concentrations of Cyclosporine. Consider alternate therapy or monitor for signs of renal and hepatic toxicity.
DocetaxelTestosterone may increase the serum levels and toxicity of docetaxel.
AcenocoumarolThe androgen, Testosterone, may incrase the anticoagulant effect of the Vitamin K antagonist, Acenocoumarol. Monitor for changes in the therapeutic effect of Acenocoumarol if Testosterone is initiated, discontinued or dose changed.
WarfarinTestosterone may increase the serum concentration and anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if testosterone is initiated, discontinued or dose changed.
show more »

Targets


Enzymes


Transporters


Carriers