QuickView for Tex42 (gene)

Gene Symbol:

NFX1 Homo sapiens

Full name:

nuclear transcription factor, X-box binding 1

Synonyms:

NFX2, TEG-42, Tex42, transcriptional repressor NF-X1, nuclear transcription factor, X box-binding protein 1

Genomic Location:

Chr 9: 33280510-33361155

Description:

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other ...

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MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

USF_Q6 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  MAX_01 ,  ARNT_02 ,  USF_01 ,  USF_Q6_01 ,  CEBP_C ,  GKCGCNNNNNNNTGAYG_UNKNOWN ,  TCCATTKW_UNKNOWN ,  USF_02

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Cytogenetic Map:

9p13.3

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