QuickView for Tgfb-3 (gene)

Gene Symbol:

Tgfb3 Mus musculus

Full name:

transforming growth factor, beta 3

Synonyms:

TGF-beta-3, Tgfb-3, transforming growth factor beta-3

Genomic Location:

Chr 12: 87397694-87419484

Description:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-a...

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Homozygous knockout mice for this gene exhibit cleft palate, delayed pulmonary development and neonatal death.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E47_01 ,  AACTTT_UNKNOWN ,  IRF1_01 ,  IRF2_01 ,  TAL1ALPHAE47_01 ,  CEBPB_02 ,  ARP1_01 ,  SRY_02 ,  AP4_Q5 ,  TATA_C ,  LMO2COM_01 ,  MIF1_01 ,  RFX1_02 ,  TCF11_01 ,  FREAC2_01 ,  FREAC3_01 ,  FREAC4_01 ,  NFAT_Q6 ,  ETS1_B ,  PAX4_03 ,  PAX4_04 ,  AMEF2_Q6 ,  RSRFC4_Q2 ,  TITF1_Q3 ,  VDR_Q3 ,  FOXO1_02 ,  FOXO4_02 ,  FOXO3_01 ,  CDC5_01 ,  NKX62_Q2 ,  RP58_01 ,  CTTTAAR_UNKNOWN ,  FOXM1_01 ,  GCM_Q2 ,  PTF1BETA_Q6 ,  TCF1P_Q6 ,  ALPHACP1_01 ,  E12_Q6 ,  HEB_Q6 ,  TFIII_Q6 ,  GCCNNNWTAAR_UNKNOWN ,  MYOGENIN_Q6 ,  HNF3ALPHA_Q6 ,  HP1SITEFACTOR_Q6 ,  CIZ_01 ,  P53_DECAMER_Q2 ,  ETS_Q4 ,  NFY_Q6_01 ,  HNF3_Q6 ,  CREB_Q3 ,  PAX_Q6 ,  FOX_Q2 ,  CREB_Q2_01 ,  AP4_Q6_01 ,  DR4_Q2 ,  DR3_Q4 ,  CTTTGTA_MIR524 ,  WTTGKCTG_UNKNOWN ,  YTCCCRNNAGGY_UNKNOWN ,  CAGCTG_AP4_Q5 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  RYTTCCTG_ETS2_B ,  TTGTTT_FOXO4_01 ,  RTAAACA_FREAC2_01 ,  GGGAGGRR_MAZ_Q6 ,  YTATTTTNR_MEF2_02 ,  TGACAGNY_MEIS1_01 ,  CACGTG_MYC_Q2 ,  TGCCAAR_NF1_Q6 ,  TGGAAA_NFAT_Q4_01 ,  GGGTGGRR_PAX4_03 ,  TATAAA_TATA_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29

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