QuickView for Tgfb4 (gene)

Gene Symbol:

LEFTY2 Homo sapiens

Full name:

left-right determination factor 2

Synonyms:

EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2, TGF-beta-4, endometrial bleeding-associated factor, left-right determination factor A, protein lefty-2, protein lefty-A, transforming growth factor beta-4

Genomic Location:

Chr 1: 224190926-224195543

Description:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature ...

View Full Description

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YTCCCRNNAGGY_UNKNOWN ,  TATAAA_TATA_01 ,  ER_Q6_02 ,  SMAD_Q6 ,  PPARA_02

Cytogenetic Map:

1q42.12

search → result