QuickView for Tgfbi (gene)

Gene Symbol:

TGFBI Homo sapiens

Full name:

transforming growth factor beta induced

Synonyms:

BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1, transforming growth factor-beta-induced protein ig-h3, RGD-CAP, RGD-containing collagen-associated protein, beta ig-h3, betaig-h3, kerato-epithelin, transforming growth factor beta-induced 68kDa, transforming growth factor, beta-induced, 68kD

Genomic Location:

Chr 5: 135392597-135427406

Description:

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in...

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This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATAAGCT_MIR21 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CAGGTA_AREB6_01 ,  ACCAAAG_MIR9 ,  TAATAAT_MIR126 ,  RACTNNRTTTNC_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

5q31.1

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