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PubChem
| Name: | Thiabendazole |
|---|---|
| PubChem Compound ID: | 5430 |
| Description: | 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919) |
| Molecular formula: | C10H7N3S |
| Molecular weight: | 201.249 g/mol |
| Synonyms: |
SMR000058170; CCRIS 4510; NINDS_000072; G 491; Ormogal; 8027-10-9; Sistesan; 4-(2-benzimidazolyl)thiazole; Tiabendazol [INN-Spanish, French]; Spectrum2_001331.
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DrugBank
Identification
| Name: | Thiabendazole |
|---|---|
| Name (isomeric): | DB00730 |
| Drug Type: | small molecule |
| Description: | 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919) |
| Synonyms: |
TBDZ; Thiabenzazole; Thiabendazol; Thiabenzole; Tiabendazole; TBZ; 2-(1,3-Thiazol-4-yl)-1H-benzimidazole; Thiabendole; Tiabendazol
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| Brand: | TBZ 6, Triasox, Thibenzole att, Ormogal, Thibenzole 200, Hokustar hp, Minzolum, Apl-Luster, Tecto rph, Tecto B, Tubazole, Mertect 160, Tecto 10P, Mycozol, Eprofil, Hymush, Sanaizol 100, Mertect 340f, Tecto 40F, Tiabenda, Bioguard, Drawipas, TBZ 60W, Top form wormer, Lombristop, Thiprazole, Tobaz, Metasol TK 100, Mintesol, Sistesan, Polival, Mertec, Tecto 60, Thiaben, Mintezol, Equivet TZ, Cropasal, Equizole, Tebuzate, Arbotect, Nemapan, Omnizole, Thibenzole, Mertect, Nemacin, Thibendole, Tibimix 20, Bovizole, Tecto, Metasol TK 10, Storite, Thibenzol, Chemviron TK 100, Mertect lsp, Testo, RPH |
| Brand name mixture: | Tresaderm Dermatologic Solution(Dexamethasone + Neomycin sulfate + Thiabendazole) |
| Category: | Anthelmintics, Antinematodal Agents |
| CAS number: | 148-79-8 |
Pharmacology
| Indication: | For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis. |
|---|---|
| Pharmacology: |
Thiabendazole is a fungicide and parasiticide. Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. Thiabendazole is vermicidal and/or vermifugal against Ascaris lumbricoides ("common roundworm"), Strong...
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| Mechanism of Action: | The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase. |
| Absorption: | Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin. |
| Biotransformation: | Hepatic. Metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates. |
| Route of elimination: | It is metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates. |
| Half Life: | The half-life for thiabendazole in both normal and anephric patients is 1.2 hours (range 0.9 to 2 hours). The half-life for the 5-hydroxythiabendazole metabolite in both normal and anephric patients is 1.7 hours (range 1.4 to 2 hours). |
| Toxicity: | Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively. |
| Affected organisms: | Roundworms, hookworms, and other helminth species |
Interactions
| Drug interaction: |
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Targets
Enzymes
