Bookmark
Forward
QuickView for Thiopental (compound)
PubChem
| Name: | Thiopental |
|---|---|
| PubChem Compound ID: | 3000715 |
| Description: | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. |
| Molecular formula: | C11H18N2O2S |
| Molecular weight: | 242.339 g/mol |
| Synonyms: |
Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio-; 59709-53-4; DEA No. 2100; Thiomebumal; 76-75-5; 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-; Thiopentobarbituric acid; 5-24-09-00172 (Beilstein Handbook Reference); AIDS018477; Thiopentobarbital.
show more » |
DrugBank
Identification
| Name: | Thiopental |
|---|---|
| Name (isomeric): | DB00599 |
| Drug Type: | small molecule |
| Description: | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. |
| Synonyms: |
Thiopentobarbitone; Thionembutal; Thiomebumal; Thiopentobarbituric acid; Penthiobarbital; Pentothal; Thiopentobarbital; Pentothiobarbital; Tiopentale [Italian]; Thiopentone
|
| Brand: | Farmotal, Thiothal, Trapanal, Nesdonal, Intraval |
| Brand name mixture: | Thiotal 5g(Thiopental Sodium + Water) |
| Category: | Anesthetics, Intravenous, GABA Modulators, Hypnotics and Sedatives, Anticonvulsants |
| CAS number: | 76-75-5 |
Pharmacology
| Indication: | For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders. |
|---|---|
| Pharmacology: |
Thiopental, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Thiopental is an ultrashort-acting depressant of the central nervous system which induces hypnosis a...
show more » |
| Mechanism of Action: | Thiopental binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. |
| Absorption: | Rapidly absorbed. |
| Protein binding: | Approximately 80% of the drug in the blood is bound to plasma protein. |
| Biotransformation: | Primarily hepatic. Biotransformation products of thiopental are pharmacologically inactive and mostly excreted in the urine. |
| Half Life: | 3-8 hours |
| Toxicity: | Overdosage may occur from too rapid or repeated injections. Too rapid injection may be followed by an alarming fall in blood pressure even to shock levels. Apnea, occasional laryngospasm, coughing and other respiratory difficulties with excessive or too rapid injections may occur. Lethal blood levels may be as low as 1 mg/100 mL for short-acting barbiturates; less if other depressant drugs or alcohol are also present. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
|
|---|
Targets
Enzymes
