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QuickView for Thioproperazine (compound)


PubChem
Name: thioproperazine
PubChem Compound ID: 92178
Molecular formula: C24H38N4O8S4
Molecular weight: 638.845 g/mol
Synonyms:
Thioproperazine bis-methanesulfonate; NCGC00017040-01; 2347-80-0; Thioproperazine methanesulfonate; Majeptil; Thioproperazine mesilate (JAN); Thioproperazine dimethanesulfonate; Thioproperazine dimesilate; CAS-2347-80-0; Thioproperazine mesylate.
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DrugBank
Identification
Name: thioproperazine
Name (isomeric): DB01622
Drug Type: small molecule
Synonyms:
Thioproperazin; Thioperazine; Thioproperazinum [inn-latin]; Tioproferazina [inn-spanish]; Thiproperazine
Brand: Vontil, Sulfenazin, Mazeptyl, Mazeptil, Majeptyl, Megeptil, Cephalmin
Category: Phenothiazines, Antipsychotic Agents
CAS number: 316-81-4
Pharmacology
Indication: For the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.
Pharmacology: Thioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property.
Mechanism of Action:
Thioproperazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an atte...
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Toxicity: Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food to avoid irritation
Avoid alcohol
Drug interaction:
DonepezilPossible antagonism of action
RivastigminePossible antagonism of action
GalantaminePossible antagonism of action

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