Name: | thioproperazine |
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PubChem Compound ID: | 92178 |
Molecular formula: | C24H38N4O8S4 |
Molecular weight: | 638.845 g/mol |
Synonyms: |
Thioproperazine bis-methanesulfonate; NCGC00017040-01; 2347-80-0; Thioproperazine methanesulfonate; Majeptil; Thioproperazine mesilate (JAN); Thioproperazine dimethanesulfonate; Thioproperazine dimesilate; CAS-2347-80-0; Thioproperazine mesylate.
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Name: | thioproperazine |
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Name (isomeric): | DB01622 |
Drug Type: | small molecule |
Synonyms: |
Thioproperazin; Thioperazine; Thioproperazinum [inn-latin]; Tioproferazina [inn-spanish]; Thiproperazine
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Brand: | Vontil, Sulfenazin, Mazeptyl, Mazeptil, Majeptyl, Megeptil, Cephalmin |
Category: | Phenothiazines, Antipsychotic Agents |
CAS number: | 316-81-4 |
Indication: | For the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes. |
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Pharmacology: | Thioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property. |
Mechanism of Action: |
Thioproperazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an atte...
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Toxicity: | Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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