QuickView for Thpok (gene)

Gene Symbol:

ZBTB7B Homo sapiens

Full name:

zinc finger and BTB domain containing 7B

Synonyms:

CKROX, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, zinc finger and BTB domain-containing protein 7B, T-helper-inducing POZ/Krueppel-like factor, krueppel-related zinc finger protein cKrox, zinc finger and BTB domain containing 15, zinc finger protein 67 homolog, zinc finger protein 857B, zinc finger protein Th-POK

Genomic Location:

Chr 1: 153241736-153257623

Description:

This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced tran...

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This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CCCAGAG_MIR326 ,  RYTTCCTG_ETS2_B ,  GATA_Q6 ,  GATA_C ,  SREBP1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  CAGGTG_E12_Q6 ,  ETS2_B ,  LMO2COM_02 ,  GATA6_01 ,  NERF_Q2 ,  ELK1_01 ,  GATA1_05 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-326

Cytogenetic Map:

1q21.3

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