QuickView for Thra2 (gene)

Gene Symbol:

THRA Homo sapiens

Full name:

thyroid hormone receptor, alpha

Synonyms:

AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor alpha, EAR-7, ERBA-related 7, V-erbA-related protein 7, c-erbA-alpha, nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), thyroid normone nuclear receptor alpha variant 1, triiodothyronine receptor

Genomic Location:

Chr 17: 35472589-35503646

Description:

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different funct...

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The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  PBX1_02 ,  RTAAACA_FREAC2_01 ,  OCT1_05 ,  CEBPA_01 ,  OCT1_B ,  GGGATGC_MIR3245P ,  OCT1_04 ,  EFC_Q6 ,  VDR_Q3 ,  OCT1_01 ,  HOXA4_Q2 ,  FOXO4_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  YGTCCTTGR_UNKNOWN ,  NKX3A_01 ,  CEBP_Q2_01 ,  HNF1_C ,  ZIC3_01 ,  GTGCAAA_MIR507 ,  NKX22_01 ,  AP2ALPHA_01 ,  OCT1_Q5_01 ,  EGR2_01 ,  OCT_C ,  WHN_B ,  GGGAGGRR_MAZ_Q6 ,  GGGNRMNNYCAT_UNKNOWN ,  STAT_Q6 ,  CREBP1_Q2 ,  TFIII_Q6 ,  CEBP_Q2 ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  GGGYGTGNY_UNKNOWN ,  GTGACGY_E4F1_Q6 ,  FREAC3_01 ,  CAGGTG_E12_Q6 ,  E47_02 ,  TGCGCANK_UNKNOWN ,  GAGCTGG_MIR337 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  AREB6_01 ,  CEBPB_02 ,  CCCNNGGGAR_OLF1_01 ,  FOXO1_01 ,  E47_01 ,  GCM_Q2 ,  SP1_Q6 ,  MEIS1_01 ,  TGTTTGY_HNF3_Q6 ,  PTF1BETA_Q6 ,  GACAGGG_MIR339 ,  TCTCTCC_MIR185 ,  AREB6_03 ,  NCX_01 ,  OCT1_02 ,  FREAC2_01 ,  CEBP_Q3 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  PIT1_Q6 ,  PAX5_01 ,  SMAD4_Q6 ,  GTGGGTGK_UNKNOWN ,  T3R_Q6 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  ZF5_B ,  ERR1_Q2 ,  FOXO4_02 ,  HNF6_Q6 ,  CACTTTG_MIR520G_MIR520H ,  SP1_Q2_01 ,  GGGTGGRR_PAX4_03 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-500

Cytogenetic Map:

17q21.1

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