QuickView for Thrb (gene)

Gene Symbol:

THRB Homo sapiens

Full name:

thyroid hormone receptor beta

Synonyms:

C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, nuclear receptor subfamily 1 group A member 2, oncogene ERBA2, thyroid hormone nuclear receptor beta variant 1, thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

Genomic Location:

Chr 3: 24134709-24511317

Description:

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different funct...

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The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATAAGCT_MIR21 ,  TGANTCA_AP1_C ,  AGTTCTC_MIR146A_MIR146B ,  AAGCCAT_MIR135A_MIR135B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CAGTGTT_MIR141_MIR200A ,  GTACTGT_MIR101 ,  TAGCTTT_MIR9 ,  IRF1_Q6 ,  ACTGTGA_MIR27A_MIR27B ,  GGGAGGRR_MAZ_Q6 ,  GGTGTGT_MIR329 ,  TGCAAAC_MIR452 ,  CACCAGC_MIR138 ,  TGCCTTA_MIR124A ,  GACAATC_MIR219 ,  ACTGCCT_MIR34B ,  TAATAAT_MIR126 ,  CTTTAAR_UNKNOWN ,  OCT1_02 ,  CGGTGTG_MIR220 ,  YNGTTNNNATT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1

Cytogenetic Map:

3p24.2

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