QuickView for Thrombomodulin (gene)

Gene Symbol:

THBD Homo sapiens

Full name:

thrombomodulin

Synonyms:

AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, CD141 antigen, fetomodulin

Genomic Location:

Chr 20: 22974270-22978301

Description:

The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thr...

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The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAGCTTT_MIR9 ,  TATAAA_TATA_01 ,  GGGCGGR_SP1_Q6 ,  CTAGGAA_MIR384

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-384

Cytogenetic Map:

20p11.21

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