QuickView for Tia1 (gene)

Gene Symbol:

TIA1 Homo sapiens

Full name:

TIA1 cytotoxic granule associated RNA binding protein

Synonyms:

TIA-1, WDM, nucleolysin TIA-1 isoform p40, nucleolysin TIA-1, T-cell-restricted intracellular antigen-1, p40-TIA-1 (containing p15-TIA-1)

Genomic Location:

Chr 2: 70292318-70329251

Description:

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The ...

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The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  CATTGTYY_SOX9_B1 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  IRF1_Q6 ,  GCCATNTTG_YY1_Q6 ,  SOX9_B1 ,  ATCATGA_MIR433 ,  YY1_Q6 ,  CATGTAA_MIR496 ,  TGCGCANK_UNKNOWN ,  AAGWWRNYGGC_UNKNOWN ,  PAX8_B ,  GATGKMRGCG_UNKNOWN ,  YY1_02 ,  IRF7_01 ,  CCCNNNNNNAAGWT_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-151 ,  Predicted Gene Targets for miR-496

miRNA binding sites
(Source: miRecords):

hsa-miR-15a/hsa-miR-16 Targeted Genes

Cytogenetic Map:

2p13.3

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